Valor pronóstico del speckle-tracking bidimensional en pacientes con sospecha de cardiopatía isquémica

Ángel Y. Rodríguez Navarro, Aylen Pérez Barreda, Ronald Aroche Aportela, Katia Ravelo Llanes, Idalys M. Román Fernández, Joanna de Zayas Galguera

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Resumen

Introducción: El estudio ecocardiográfico mediante speckle-tracking ha emergido como un novedoso método para la evaluación cuantitativa de la función miocárdica y se ha correlacionado con la presencia de enfermedad coronaria.

Objetivo: Determinar el valor pronóstico de la deformación miocárdica (strain) por speckle-tracking bidimensional en la evolución de pacientes con sospecha de cardiopatía isquémica.

Método: Estudio longitudinal prospectivo analítico con 51 pacientes a los que se realizó ecocardiograma con evaluación de la deformación (strain) longitudinal global por speckle-tracking bidimensional y coronariografía en el CIMEQ entre 2016 y 2018. Se siguieron los eventos cardíacos graves (infarto de miocardio, muerte cardíaca y por otras causas, enfermedad cerebrovascular y necesidad de nueva revascularización).

Resultados: El 70,6% de los enfermos resultaron ser del sexo masculino, el 81,4% mayores de 50 años y 81,4%, fumadores. El 65,0% tenía enfermedad coronaria significativa y 55,0% de los casos fueron revascularizados. Se registraron 4 muertes (7,8%) y un infarto no fatal (2,0%). Los pacientes con deformación longitudinal global ≤ -15% (en valores absolutos) tuvieron mayor frecuencia de eventos cardíacos graves (p=0,02).

Conclusiones: La deformación longitudinal global medida por speckle-tracking bidimensional no pudo predecir la presencia de enfermedad coronaria, pero sí los eventos cardiovasculares graves en los enfermos con enfermedad coronaria significativa.

Referencias

Mada RO, Duchenne J, Voigt JU. Tissue Doppler, strain and strain rate in ischemic heart disease "how I do it". Cardiovasc Ultrasound [Internet]. 2014 [citado 23 May 2020];12:38. Disponible en: https://doi.org/10.1186/1476-7120-12-38

Kossaify A, Bassil E, Kossaify M. Stress Echocardiography: Concept and Criteria, Structure and Steps, Obstacles and Outcomes, Focused Update and Review. Cardiol Res. 2020;11(2):89-96. [DOI] https://doi.org/10.14740/cr851

Luis SA, Chan J, Pellikka PA. Echocardiographic Assessment of Left Ventricular Systolic Function: An Overview of Contemporary Techniques, Including Speckle-Tracking Echocardiography. Mayo Clin Proc. 2019;94(1):125-38. [DOI] https://doi.org/10.1016/j.mayocp.2018.07.017

Centro Nacional de Información de Ciencias Médicas. Cardiopatía isquémica. Estadísticas Mundiales. Factográfico Salud [Internet]. 2019 [citado 23 May 2020];5(2). Disponible en: http://files.sld.cu/bmn/files/2019/02/factografico-de-salud-febrero-2019.pdf

Ministerio de Salud Pública. Anuario Estadístico de Salud 2018. La Habana: Dirección de Registros Médicos y Estadísticas de Salud; 2019.

Rivas Estany E, Barrera Sarduy JD, Henry Vera G. Prueba de esfuerzo bajo control electrocardiográfico. Revisión de guías internacionales y normas cubanas. Rev Cuban Cardiol [Internet]. 2020 [citado 20 May 2020];26(2). Disponible en: http://www.revcardiologia.sld.cu/index.php/revcardiologia/article/view/925/pdf

Knuuti J, Wijns W, Saraste A, Capodanno D, Barbato E, Funck-Brentano C, et al. Guía ESC 2019 sobre el diagnóstico y tratamiento de los síndromes coronarios crónicos. Rev Esp Cardiol. 2020;73(6):495.e1-e61. [DOI] https://doi.org/10.1016/j.recesp.2019.10.032

Radwan H, Hussein E. Value of global longitudinal strain by two dimensional speckle tracking echocardiography in predicting coronary artery disease severity. Egypt Heart J. 2017;69(2):95-101. [DOI] https://doi.org/10.1016/j.ehj.2016.08.001

Moustafa S, Elrabat K, Swailem F, Galal A. The correlation between speckle tracking echocardiography and coronary artery disease in patients with suspected stable angina pectoris. Indian Heart J. 2018;70(3):379-86. [DOI] https://doi.org/10.1016/j.ihj.2017.09.220

Hubbard RT, Arciniegas Calle MC, Barros-Gomes S, Kukuzke JA, Pellikka PA, Gulati R, et al. 2-Dimensional Speckle Tracking Echocardiography predicts severe coronary artery disease in women with normal left ventricular function: a case-control study. BMC Cardiovasc Disord [Internet]. 2017 [citado 20 May 2020];17(1):231. Disponible en: https://doi.org/10.1186/s12872-017-0656-5

Amundsen BH, Helle-Valle T, Edvardsen T, Torp H, Crosby J, Lyseggen E, et al. Noninvasive myocardial strain measurement by speckle tracking echocardiography: validation against sonomicrometry and tagged magnetic resonance imaging. J Am Coll Cardiol. 2006;47(4):789-93. [DOI] https://doi.org/10.1016/j.jacc.2005.10.040

Scharrenbroich J, Hamada S, Keszei A, Schröder J, Napp A, Almalla M, et al. Use of two-dimensional speckle tracking echocardiography to predict cardiac events: Comparison of patients with acute myocardial infarction and chronic coronary artery disease. Clin Cardiol. 2018;41(1):111-8. [DOI] https://doi.org/10.1002/clc.22860

Hu B, Zhou Q, Yao X, Tan T, Lei J, Cao Q, et al. Layer-specific strain for long-term outcome prediction after first-onset myocardial infarction. Ultrasound Med Biol. 2020;46(6):1435-41. [DOI] https://doi.org/10.1016/j.ultrasmedbio.2020.02.013

Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2015;28(1):1-39.e14. [DOI] https://doi.org/10.1016/j.echo.2014.10.003

Cutlip DE, Windecker S, Mehran R, Boam A, Cohen DJ, van Es GA, et al. Clinical end points in coronary stent trials: A case for standardized definitions. Circulation. 2007;115(17):2344-51. [DOI] https://doi.org/10.1161/circulationaha.106.685313

Hernández Navas M, Aroche Aportela R, Aldama Pérez L, Obregón Santos Á, Gil Torres I, Leal Hernández E. Importancia clínica del sangrado en pacientes con intervencionismo coronario percutáneo por vía radial en el CIMEQ. CorSalud [Internet]. 2015 [citado 25 May 2020];7(3),175-80. Disponible en: http://www.revcorsalud.sld.cu/index.php/cors/article/view/55/113

Armas Rojas NA, Dueñas Herrera A, de la Noval García R, Ortega Torres Y, Acosta González M, Morales Salinas A. Cardiopatía Isquémica en Cuba. Una puesta al día. Rev Cuban Cardiol [Internet]. 2015 [citado 25 May 2020];21(3). Disponible en: http://www.revcardiologia.sld.cu/index.php/revcardiologia/article/view/597/pdf_15

Nafeh AM, Hernández NR, Carballo HN, Villar IA, Guevara GL, Chaos GN, et al. Resultados de la revascularización coronaria en el Cardiocentro del Hospital «Hermanos Ameijeiras», en un período de 20 años. Rev Cuba Cir. 2011;50(1):54-72.

Santos Pérez A, Pérez López H, Valero Hernández A, Lage López L, Borges Moreno YR. Factores preoperatorios relacionados con las complicaciones cardiovasculares de la cirugía de revascularización coronaria. Gac Méd Espirit [Internet]. 2010 [citado 26 May 2020];12(3). Disponible en: http://revgmespirituana.sld.cu/index.php/gme/article/view/1549/1700

Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, et al. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2019;74(10):1376-414. [DOI] https://doi.org/10.1016/j.jacc.2019.03.009

Aldama Pérez LI, Naranjo Domínguez A, Hernández Navas M, García Hernández RA, Aroche Aportela R, Cuba Rodríguez AL. Intervencionismo percutáneo en la enfermedad coronaria de tres vasos. Seguimiento de dos años. Rev Cuban Cardiol [Internet]. 2019 [citado 26 May 2020];25(3). Disponible en: http://www.revcardiologia.sld.cu/index.php/revcardiologia/article/view/887/pdf

Alfonso Alfonso Y, Roque Pérez L, de la Cruz Pérez D, Pérez Fierro M, Batista Mestre I, Díaz Águila HR. Caracterización de los factores de riesgo en pacientes con cardiopatía isquémica Hospital “Mártires del 9 de Abril”, período 2016-2017. Rev Med Electrón [Internet]. 2019 [citado 28 May 2020];41(4). Disponible en: http://www.revmedicaelectronica.sld.cu/index.php/rme/article/view/2841/pdf_665

Rodríguez Navarro AY, Naranjo Domínguez AA, Aroche Aportela R. Factores de riesgo en pacientes con síndrome coronario agudo remitidos para coronariografía. CorSalud [Internet]. 2013 [citado 28 May 2020];5(3):280-4. Disponible en: http://www.revcorsalud.sld.cu/index.php/cors/article/view/527/943

De Servi S, Olivari Z, Crimi G, Marino M, Alberti LP, Tagliabue E, et al. Percutaneous coronary interventions for stable ischemic heart disease in Italy. J Cardiovasc Med (Hagerstown). 2019;20(11):762-7. [DOI] https://doi.org/10.2459/jcm.0000000000000835

Madhavan S, Narayanapillai J, Paikada JS, Jayaprakash K, Jayaprakash V. Two-dimensional speckle tracking echocardiography as a predictor of significant coronary artery stenosis in female patients with effort angina who are treadmill test positive: An angiographic correlation. J Clin Prev Cardiol. 2019;8(3):126-30. [DOI] https://doi.org/10.4103/JCPC.JCPC_6_19

Hagemann CA, Hoffmann S, Hagemann RA, Fritz-Hansen T, Olsen FJ, Jørgensen PG, et al. Usefulness of layer-specific strain in diagnosis of coronary artery disease in patients with stable angina pectoris. Int J Cardiovasc Imaging. 2019;35(11):1989-99. [DOI] https://doi.org/10.1007/s10554-019-01652-3

Biering-Sørensen T, Hoffmann S, Mogelvang R, Zeeberg Iversen A, Galatius S, Fritz-Hansen T, et al. Myocardial strain analysis by 2-dimensional speckle tracking echocardiography improves diagnostics of coronary artery stenosis in stable angina pectoris. Circ Cardiovasc Imaging. 2014;7(1):58-65. [DOI] https://doi.org/10.1161/circimaging.113.000989

Choi JO, Cho SW, Song YB, Cho SJ, Song BG, Lee SC, et al. Longitudinal 2D strain at rest predicts the presence of left main and three vessel coronary artery disease in patients without regional wall motion abnormality. Eur J Echocardiogr. 2009;10(5):695-701. [DOI] https://doi.org/10.1093/ejechocard/jep041

Norum IB, Ruddox V, Edvardsen T, Otterstad JE. Diagnostic accuracy of left ventricular longitudinal function by speckle tracking echocardiography to predict significant coronary artery stenosis. A systematic review. BMC Med Imaging [Internet]. 2015 [citado 31 May 2020];15:25. Disponible en: https://doi.org/10.1186/s12880-015-0067-y

Bakhoum SWG, Taha HS, Abdelmonem YY, Fahim MAS. Value of resting myocardial deformation assessment by two dimensional speckle tracking echocardiography to predict the presence, extent and localization of coronary artery affection in patients with suspected stable coronary artery disease. The Egypt Heart J. 2016;68(3):171-9. [DOI] http://dx.doi.org/10.1016/j.ehj.2016.02.001

Sarvari SI, Haugaa KH, Zahid W, Bendz B, Aakhus S, Aaberge L, et al. Layer-specific quantification of myocardial deformation by strain echocardiography may reveal significant CAD in patients with non-ST-segment elevation acute coronary syndrome. JACC Cardiovasc Imaging. 2013;6(5):535-44. [DOI] https://doi.org/10.1016/j.jcmg.2013.01.009

Zhang L, Wu WC, Ma H, Wang H. Usefulness of layer-specific strain for identifying complex CAD and predicting the severity of coronary lesions in patients with non-ST-segment elevation acute coronary syndrome: Compared with Syntax score. Int J Cardiol. 2016;223:1045-52. [DOI] https://doi.org/10.1016/j.ijcard.2016.08.277

Lacalzada J, de la Rosa A, Izquierdo MM, Jiménez JJ, Iribarren JL, García-González MJ, et al. Left ventricular global longitudinal systolic strain predicts adverse remodeling and subsequent cardiac events in patients with acute myocardial infarction treated with primary percutaneous coronary intervention. Int J Cardiovasc Imaging. 2015;31(3):575-84. [DOI] https://doi.org/10.1007/s10554-015-0593-2

Nahum J, Bensaid A, Dussault C, Macron L, Clémence D, Bouhemad B, et al. Impact of longitudinal myocardial deformation on the prognosis of chronic heart failure patients. Circ Cardiovasc Imaging. 2010;3(3):249-56. [DOI] https://doi.org/10.1161/circimaging.109.910893

Zhang KW, French B, May Khan A, Plappert T, Fang JC, Sweitzer NK, et al. Strain improves risk prediction beyond ejection fraction in chronic systolic heart failure. J Am Heart Assoc [Internet]. 2014 [citado 31 May 2020];3(1):e000550. Disponible en: https://doi.org/10.1161/jaha.113.000550

Cho GY, Marwick TH, Kim HS, Kim MK, Hong KS, Oh DJ. Global 2-dimensional strain as a new prognosticator in patients with heart failure. J Am Coll Cardiol. 2009;54(7):618-24. [DOI] https://doi.org/10.1016/j.jacc.2009.04.061

Hung CL, Verma A, Uno H, Shin SH, Bourgoun M, Hassanein AH, et al. Longitudinal and circumferential strain rate, left ventricular remodeling, and prognosis after myocardial infarction. J Am Coll Cardiol. 2010;56(22):1812-22. [DOI] https://doi.org/10.1016/j.jacc.2010.06.044

Ersbøll M, Valeur N, Mogensen UM, Andersen MJ, Møller JE, Velazquez EJ, et al. Prediction of all-cause mortality and heart failure admissions from global left ventricular longitudinal strain in patients with acute myocardial infarction and preserved left ventricular ejection fraction. J Am Coll Cardiol. 2013;61(23):2365-73. [DOI] https://doi.org/10.1016/j.jacc.2013.02.061

Bertini M, Ng AC, Antoni ML, Nucifora G, Ewe SH, Auger D, et al. Global longitudinal strain predicts long-term survival in patients with chronic ischemic cardiomyopathy. Circ Cardiovasc Imaging. 2012;5(3):383-91. [DOI] https://doi.org/10.1161/circimaging.111.970434

Potter E, Marwick TH. Assessment of left ventricular function by echocardiography: The case for routinely adding global longitudinal strain to ejection fraction. JACC Cardiovasc Imaging. 2018;11(2 Pt 1):260-74. [DOI] https://doi.org/10.1016/j.jcmg.2017.11.017

Thavendiranathan P, Poulin F, Lim KD, Plana JC, Woo A, Marwick TH. Use of myocardial strain imaging by echocardiography for the early detection of cardiotoxicity in patients during and after cancer chemotherapy: A systematic review. J Am Coll Cardiol. 2014;63(25 Pt A):2751-68. [DOI] https://doi.org/10.1016/j.jacc.2014.01.073

Yingchoncharoen T, Gibby C, Rodriguez LL, Grimm RA, Marwick TH. Association of myocardial deformation with outcome in asymptomatic aortic stenosis with normal ejection fraction. Circ Cardiovasc Imaging. 2012;5(6):719-25. [DOI] https://doi.org/10.1161/circimaging.112.977348

Liu H, Pozios I, Haileselassie B, Nowbar A, Sorensen LL, Phillip S, et al. Role of global longitudinal strain in predicting outcomes in hypertrophic cardiomyopathy. Am J Cardiol. 2017;120(4):670-5. [DOI] https://doi.org/10.1016/j.amjcard.2017.05.039

Kuznetsova T, Herbots L, Richart T, D'hooge J, Thijs L, Fagard RH, et al. Left ventricular strain and strain rate in a general population. Eur Heart J. 2008;29(16):2014-23. [DOI] https://doi.org/10.1093/eurheartj/ehn280

Jensen MT, Sogaard P, Andersen HU, Bech J, Fritz Hansen T, Biering-Sørensen T, et al. Global longitudinal strain is not impaired in type 1 diabetes patients without albuminuria: the Thousand & 1 study. JACC Cardiovasc Imaging. 2015;8(4):400-10. [DOI] https://doi.org/10.1016/j.jcmg.2014.12.020

Narayanan A, Aurigemma GP, Chinali M, Hill JC, Meyer TE, Tighe DA. Cardiac mechanics in mild hypertensive heart disease: a speckle-strain imaging study. Circ Cardiovasc Imaging. 2009;2(5):382-90. [DOI] https://doi.org/10.1161/circimaging.108.811620

Wong CY, O'Moore-Sullivan T, Leano R, Byrne N, Beller E, Marwick TH. Alterations of left ventricular myocardial characteristics associated with obesity. Circulation. 2004;110(19):3081-7. [DOI] https://doi.org/10.1161/01.cir.0000147184.13872.0F

Lauridsen TK, Alhede C, Crowley AL, Kisslo J, Sørensen LL, Hansen TF, et al. Two-dimensional global longitudinal strain is superior to left ventricular ejection fraction in prediction of outcome in patients with left-sided infective endocarditis. Int J Cardiol. 2018;260:118-23. [DOI] https://doi.org/10.1016/j.ijcard.2018.01.031

Khidir MJH, Abou R, Yilmaz D, Ajmone Marsan N, Delgado V, Bax JJ. Prognostic value of global longitudinal strain in heart failure patients treated with cardiac resynchronization therapy. Heart Rhythm. 2018;15(10):1533-9. [DOI] https://doi.org/10.1016/j.hrthm.2018.03.034

Yadlapati A, Maher TR, Thomas JD, Gajjar M, Ogunyankin KO, Puthumana JJ. Global longitudinal strain from resting echocardiogram is associated with long-term adverse cardiac outcomes in patients with suspected coronary artery disease. Perfusion. 2017;32(7):529-37. [DOI] https://doi.org/10.1177/0267659117701563

Felekos I, Aggeli C, Gialafos E, Kouranos V, Rapti A, Sfikakis P, et al. Global longitudinal strain and long-term outcomes in asymptomatic extracardiac sarcoid patients with no apparent cardiovascular disease. Echocardiography. 2018;35(6):804-8. [DOI] https://doi.org/10.1111/echo.13846

Sikora-Frac M, Zaborska B, Maciejewski P, Budaj A, Bednarz B. Improvement of left ventricular function after percutaneous coronary intervention in patients with stable coronary artery disease and preserved ejection fraction: Impact of diabetes mellitus. Cardiol J. 2019. [DOI] https://doi.org/10.5603/cj.a2019.0066

Jahn L, Kramann R, Marx N, Floege J, Becker M, Schlieper G. Speckle tracking echocardiography and all-cause and cardiovascular mortality risk in chronic kidney disease patients. Kidney Blood Press Res. 2019;44(4):690-703. [DOI] https://doi.org/10.1159/000501225

Jung IH, Park JH, Lee JA, Kim GS, Lee HY, Byun YS, et al. Left ventricular global longitudinal strain as a predictor for left ventricular reverse remodeling in dilated cardiomyopathy. J Cardiovasc Imaging. 2020;28(2):137-49. [DOI] https://doi.org/10.4250/jcvi.2019.0111

Kaufmann D, Szwoch M, Kwiatkowska J, Raczak G, Daniłowicz-Szymanowicz L. Global longitudinal strain can predict heart failure exacerbation in stable outpatients with ischemic left ventricular systolic dysfunction. PLoS One [Internet]. 2019 [citado 5 Jun 2020];14(12):e0225829. Disponible en: https://doi.org/10.1371/journal.pone.0225829

Al Saikhan L, Park C, Hardy R, Hughes A. Prognostic implications of left ventricular strain by speckle-tracking echocardiography in the general population: a meta-analysis. Vasc Health Risk Manag. 2019;15:229-51. [DOI] https://doi.org/10.2147/vhrm.s206747

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