Coexistence of Brugada Sign During a Febrile Episode and an Accessory Pathway: A Curiosity?
Abstract
Fever can unmask or exacerbate an electrocardiographic Brugada pattern. Although its association with an accessory pathway is rare, its identification is important. We present the case of an asymptomatic 26‐year‐old male with a family history of sudden death (father and uncle) who exhibited a Brugada sign unmasked during a febrile episode, with subsequent spontaneous reappearance, in addition to an accessory pathway manifesting orthodromic tachycardia induced during the electrophysiological study. Conventional diagnostic tests were normal. Both the Brugada sign and the left lateral accessory pathway were evident yet intermittent. No malignant ventricular arrhythmia was induced during programmed electrical stimulation. Successful ablation of the accessory pathway was performed. The patient is currently followed on an outpatient basis, receiving quinidine and antipyretics as needed, and remains asymptomatic.
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1.Khazan B, Curl K, Ho R. Brugada Pattern With a Concurrent Accessory Pathway. JACC Clin Electrophysiol. 2017;3(8):911-2. DOI: https://doi.org/10.1016/j.jacep.2016.11.004
2.Erdoğan O. Coexistence of Wolff-Parkinson-White and Brugada ECG. Turk Kardiyol Dern Ars. 2018;46(6):433-4. DOI: https://doi.org/10.5543/tkda.2018.75271
3.Aksan G, Tezcan M, Çevrim Ö, Elitok A, Bilge AK. Coexistence of Brugada and Wolff Parkinson White syndromes: A case report and review of the literature. Turk Kardiyol Dern Ars. 2018;46(6):488-93. DOI: https://doi.org/10.5543/tkda.2018.77834
4.Kaiser E, Sacilotto L, Darrieux F, Sosa E. Coexistence of Wolff-Parkinson-white and Brugada syndrome: mere curiosity? Ann Noninvasive Electrocardiol. 2014;19(5):504-7. DOI: https://doi.org/10.1111/anec.12124
5.Bodegas AI, Arana JI, Vitoria Y, Arriandiaga JR, Barrenetxea JI. Brugada syndrome in a patient with accessory pathway. Europace. 2002;4(1):87-9. DOI: https://doi.org/10.1053/eupc.2001.0201
6.Jaiswal A, Heretis K, Goldbarg S. Coexistent Brugada Syndrome and Wolff-Parkinson-White Syndrome: What is the Optimal Management? Indian Pacing Electrophysiol J. 2013;13(5):173-7. DOI: https://doi.org/10.1016/s0972-6292(16)30669-6
7.Martini B, Martini N, Dorantes Sánchez M, Márquez MF, Zhang L, Fontaine G, et al. Pistas de una enfermedad orgánica subyacente en el síndrome de Brugada. Arch Cardiol Mex. 2017;87(1):49-60. DOI: https://doi.org/10.1016/j.acmx.2016.10.001
8.De Roy L, Popescu E, Floria M, Blommaert D, Deceuninck O, Collet B, et al. Variable morphologies of preexcitation due to a concomitant Brugada pattern. J Interv Card Electrophysiol. 2007;20(1-2):39-41. DOI: https://doi.org/10.1007/s10840-007-9166-1
9.Brugada P, Brugada J, Brugada R. Síndrome Brugada. Del laboratorio a la clínica. J&C Ediciones Médicas; 2006.
10.Adler A, Topaz G, Heller K, Zeltser D, Ohayon T, Rozovski U, et al. Fever-induced Brugada pattern: how common is it and what does it mean? Heart Rhythm. 2013;10(9):1375-82. DOI: https://doi.org/10.1016/j.hrthm.2013.07.030
11.Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D, et al. Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation. 2005;111(5):659-70. DOI: https://doi.org/10.1161/01.cir.0000152479.54298.51
12.Traub D, Fonseka N, Priori S. ST-segment elevation in the setting of a febrile illness. Ann Noninvasive Electrocardiol. 2011;16(3):303-7. DOI: https://doi.org/10.1111/j.1542-474x.2011.00445.x
13.Eckardt L, Kirchhof P, Johna R, Haverkamp W, Breithardt G, Borggrefe M. Wolff-Parkinson-White syndrome associated with Brugada syndrome. Pacing Clin Electrophysiol. 2001;24(9 Pt 1):1423-4. DOI: https://doi.org/10.1046/j.1460-9592.2001.01423.x
14.Dorantes Sánchez M, Borroto González E, Castro Hevia JA, Martínez López F, Castañeda Chirino O, Falcón Rodríguez R, et al. Preexcitación ventricular y signo de Brugada coexistentes: Una rara entidad. CorSalud [Internet]. 2022 [citado 14 Ene 2023];14(2):193-8. Disponible en: https://revcorsalud.sld.cu/index.php/cors/article/view/854/1480
15.Probst V, Veltmann C, Eckardt L, Meregalli PG, Gaita F, Tan HL, et al. Long-term prognosis of patients diagnosed with Brugada syndrome: Results from the FINGER Brugada Syndrome Registry. Circulation. 2010;121(5):635-43. DOI: https://doi.org/10.1161/circulationaha.109.887026
16.Priori SG, Gasparini M, Napolitano C, Della Bella P, Ottonelli AG, Sassone B, et al. Risk stratification in Brugada syndrome: results of the PRELUDE (PRogrammed ELectrical stimUlation preDictive valuE) registry. J Am Coll Cardiol. 2012;59(1):37-45. DOI: https://doi.org/10.1016/j.jacc.2011.08.064
17.González Rebollo JM, Hernández Madrid A, García A, García de Castro A, Mejías A, Moro C. Fibrilación ventricular recurrente durante un proceso febril en un paciente con síndrome de Brugada. Rev Esp Cardiol. 2000;53(5):755-7. DOI: https://doi.org/10.1016/s0300-8932(00)75151-7
18.Junttila MJ, Gonzalez M, Lizotte E, Benito B, Vernooy K, Sarkozy A, et al. Induced Brugada-type electrocardiogram, a sign for imminent malignant arrhythmias. Circulation. 2008;117(14):1890-3. DOI: https://doi.org/10.1161/circulationaha.107.746495
19.Amin AS, Meregalli PG, Bardai A, Wilde AA, Tan HL. Fever increases the risk for cardiac arrest in the Brugada syndrome. Ann Intern Med. 2008;149(3):216-8. DOI: https://doi.org/10.7326/0003-4819-149-3-200808050-00020
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