Significado y mecanismos de un intervalo QT prolongado en la isquemia miocárdica aguda

1. Cruz Elizundia JM, Carmona Puerta R, Pérez Cabrera D. QT prolongado que precede a la corriente de lesión en el infarto. CorSalud [Internet]. 2013 [citado 18 Dic 2012];5(1): Disponible en: http://www.corsalud.sld.cu/pdf/2013/v5n1a13/es/qt1.pdf

2. Cinca J, Figueras J, Tenorio L, Valle V, Trenchs J, Segura R, et al. Time course and rate dependence of QT interval changes during noncomplicated acute transmural myocardial infarction in human beings. Am J Cardiol.1981;48(6):1023-8.

3. Jiménez Candil J, González Matas JM, Cruz González I, Hernández Hernández J, Martín A, Pabón P, et al. Pronóstico hospitalario del síndrome coro-nario agudo sin elevación del segmento ST determinado por una nueva escala de riesgo integrada por variables electrocardiográficas obtenidas al ingreso. Rev Esp Cardiol. 2010;63(7):851-5.

4. Schwartz PJ, Wolf S. QT interval prolongation as predictor of sudden death in patients with myo-cardial infarction. Circulation. 1978;57(6):1074-7.

5. Gadaleta F, Llois S, Sinisi V, Quiles J, Avanzas P, Kaski J. Prolongación del intervalo QT corregido: nuevo predictor de riesgo cardiovascular en el síndrome coronario agudo sin elevación del ST. Rev Esp Cardiol. 2008;61(6):572-8.

6. Jiménez Candil J, Luengo M. Intervalo QT e isquemia miocárdica aguda: viejas promesas, nuevas evidencias. Rev Esp Cardiol. 2008;61(6):561-3.

7. Patel C, Burke JF, Patel H, Gupta P, Kowey PR, Antzelevitch C, Gan-Xin Y. Is there a significant trans-mural gradient in repolarization time in the intact heart? Cellular basis of the T Wave: a century of controversy. Circ Arrhythm Electrophysiol. 2009; 2(1):80-8.

8. Chauhan VS, Tang AS. Dynamic changes of QT interval and QT dispersion in non-Q-wave and Q-wave myocardial infarction. J Electrocardiol. 2001; 34(2):109-17.

9. Anyukhovsky EP, Sosunov EA, Rosen MR. Regional differences in electrophysiological properties of epicardium, midmyocardium, and endocardium: in vitro and in vivo correlations. Circulation. 1996; 94(8):1981-8.

10. Wit AL, Janse MJ. The ventricular arrhythmias of ischemia and infarction: Electrophysiological mechanisms. Armonk, NY: Futura Publishing Compa-ny; 2005.

11. Cascio W, Yan G, Kléber A. Passive electrical properties, mechanical activity, and extracellular potassium in arterially perfused and ischemic rabbit ventricular muscle. Effects of calcium entry blockade or hypocalcemia. Circ Res. 1990;66:1461-73.

12. Bethell HW, Vandenberg JI, Smith GA, Grace AA. Changes in ventricular repolarization during acidosis and low-flow ischemia. Am J Physiol. 1998; 275(2 Pt 2):H551-61.

13. Kagiyama Y, Hill JL, Gettes LS. Interaction of acidosis and increased extracellular potassium on action potential characteristics and conduction in guinea pig ventricular muscle. Circ Res 1982;51(5): 614-23.

14. Spitzer KW, Hogan PM. The effects of acidosis and bicarbonate on action potential repolarization in canine cardiac Purkinje fibers. J Gen Physiol. 1979; 73(2):199-218.

15. Shivkumar K, Deutsch NA, Lamp ST, Khuu K, Goldhaber JI, Weiss JN. Mechanism of hypoxic K loss in rabbit ventricle. J Clin Invest. 1997;100(7): 1782-8.

16. Kiyosue T, Arita M. Effects of lysophosphatidylcholine on resting potassium conductance of isolated guinea pig ventricular cells. Pflugers Arch. 1986;406(3):296-302.

17. Undrovinas AI, Fleidervish IA, Makielski JC. Inward sodium current at resting potentials in single car-diac myocytes induced by the ischemic metabolite lysophosphatidylcholine. Circ Res. 1992;71(5):1231 - 41.

18. Burnashev NA, Undrovinas AI, Fleidervish IA, Ma-kielski JC, Rosenshtraukh LV. Modulation of cardiac sodium channel gating by lysophosphatidyl-choline. J Mol Cell Cardiol. 1991;23 Suppl 1:23-30.