Electrophysiological mechanisms of the st segment elevation during acute myocardial infarction. Current hypothesis
Keywords:
elñectrocardiography, myocardial infarction, electrophysiology, physiopathologyAbstract
The origin of the ST segment elevation during acute myocardial infarction (AMI) has been the object of controversy. The advances in basic cardiac electrophysiology has made possible to assume, with a high degree of reliability, the ionic bases that generate the clinical electrocardiogram change. Starting from an electrical heterogeneity that exists in normal conditions, the acute myocardic ischemia induces an exacerbation of this physiological behavior and creates significant transmural electric gradients, which produces powerful electrical current vectors from the endocardium to the epicardium. A different response from the electrophysiological point of view, in the presence of such abnormal stimuli, creates a functional substratum for such an electric discrepancy through the thickness of the cardiac walls.
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