Electrophysiological mechanisms of the st segment elevation during acute myocardial infarction. Current hypothesis

Authors

  • Raimundo Carmona Puerta Hospital Provincial Universitario Cardiocentro Ernesto Guevara
  • Ginner O. Rizo Rivera Hospital Universitario Arnaldo Milián Castro
  • Elibet Chávez González Hospital Provincial Universitario Cardiocentro Ernesto Guevara

Keywords:

elñectrocardiography, myocardial infarction, electrophysiology, physiopathology

Abstract

The origin of the ST segment elevation during acute myocardial infarction (AMI) has been the object of controversy. The advances in basic cardiac electrophysiology has made possible to assume, with a high degree of reliability, the ionic bases that generate the clinical electrocardiogram change. Starting from an electrical heterogeneity that exists in normal conditions, the acute myocardic ischemia  induces an exacerbation of this physiological behavior and creates significant transmural electric gradients, which produces powerful electrical current vectors from the endocardium to the epicardium. A different response from the electrophysiological point of view, in the presence of such abnormal stimuli, creates a functional substratum for such an electric discrepancy through the thickness of the cardiac walls.

Downloads

Download data is not yet available.

References

1. Antzelevitch C, Dumaine R. Electrical heterogeneity in the heart: Physiological, pharmacological and clinical implications. In: Page E, Fozzard HA, Solaro RJ, editors. Handbook of physiology. Section 2. The cardiovascular system. New York: Oxford University Press; 2001. p. 654-92.

2. Antzelevitch Ch, Fish J. Electrical heterogeneity within ventricular wall. Basic Res Cardiol. 2001;96(6):517-27.

3. Carmona RP, López BV, Pérez AA. En el corazón normal no siempre se corresponden estructura microscópica y función. Medicentro Electrónica [Internet]. 2007 Ene-Mar [citado 10 Sept 2010];11(1):[aprox. 4 p.]. Disponible en:

http://medicentro.vcl.sld.cu/paginas%20de%20acceso/Sumario/ano%202007/v11n1a07/corazon.htm

4. Birnbaum SHG, Varga AW, Yuan Ll, Anderson AE, Sweatt JD, Schrader LA. Structure and function of Kv 4-family transient potassium channels. Physiol Rev. 2004;84(3):803-33. doi:10.1152/physrev.00039.2003

5. Carmona Puerta R. Síndrome de Brugada: desde los genes hasta la terapéutica. Corsalud 2010 [serial online] [citada 10 Sept 2010];2(2): 145-61: [2 p.]. Disponible en:

http://corsalud.vcl.sld.cu/sumario/2010/v2n2a10/sindromebrugada.htm

6. Antzelevitch C, Oliva A. Amplification of spatial dispersion of repolarization underlies sudden cardiac death associated with catecholaminergic polimorphic VT, long QT, short QT and Brugada syndromes. J Intern Med. 2006;259(1):48-8.

7. Antzelevitch C. Heterogeneity and cardiac arrhythmias: An overview. Heart Rhythm 2007;4(7):964-72.

8. Antzelevitch C. Role of spatial dispersion of repolarization in inhereted and acquired sudden cardiac death syndromes. Am J Physiol Heart Circ Physiol. 2007; 293(4):2024-38.

9. Antzelevitch C. Cardiac repolarization. The long and short of it. Europace. 2005 Sep;7 Suppl 2:3-9.

10. Wellens HJ. Early repolarization revisited. N Engl J Med. 2008;358(19):2063-4.

11. Riera AR, Uchida AH, Schapachnik E, Dubner S, Zhang L, Ferreira C. Early repolarization variant: epidemiological aspects, mechanism, and differential diagnosis. Cardiol J. 2008;15(1):4-16.

12. Boineau JP. The early repolarization variant-normal or a marker of heart disease in certain subjects. J Electrocardiol. 2007;40(1):3.e11-6.

13. Boineau JP. The early repolarization variant-an electrocardiographic enigma with both QRS and J-ST-T anomalies. J Electrocardiol. 2007;40(1):3.e1-10.

14. Antzelevitch C, Yan GX. J wave syndromes. Heart Rhythm. 2010;7(4):549-58.

15. Cordeiro JM, Mazza M, Goodrow R, Ulahannan N, Antzelevitch C, Di Diego JM. Functionally distinct sodium channels in ventricular epicardial and endocardial cells contribute to a greater sensitivity of the epicardium to electrical depression. Am J Physiol Heart Circ Physiol. 2008;295(1):H154-62.

Published

2010-12-27

How to Cite

1.
Carmona Puerta R, Rizo Rivera GO, Chávez González E. Electrophysiological mechanisms of the st segment elevation during acute myocardial infarction. Current hypothesis. CorSalud [Internet]. 2010 Dec. 27 [cited 2025 Sep. 11];2(4):279-85. Available from: https://revcorsalud.sld.cu/index.php/cors/article/view/1142