Subarachnoid analgesia with meperidine in gynecologic surgery of patients with hypertension
Keywords:
anesthesia and analgesia, meperidine, bupivacaine, surgery, gynecology, hypertensionAbstract
Introduction and Objectives: Spinal analgesia is a basic mainstay in gynecologic surgery. The objective of this research was to determine the usefulness of meperidine as an analgesic agent via the subarachnoid space. Method: A prospective and inferential study was performed in 20 hypertensive patients who were scheduled for elective gynecological surgery, and who were divided into two groups of 10 patients. The group- M received spinal anesthesia with meperidine 1 mg / kg and group-B patients received hyperbaric bupivacaine 0.1 mg / kg. An analysis of the postoperative analgesia time and of the incidence of side effects was made. Results: In patients who were administered meperidine, postoperative analgesia was significantly higher; numerical incidence of side effects was no different, nausea predominated in both groups, followed by pruritus with the use of meperidine and shivering with bupivacaine. Conclusions: Meperidine proved useful as an analgesic agent in hypertensive patients who underwent gynecological surgery.
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1. Cook TM, Mihai R, Wildsmith JA; Royal College of Anaesthetists Third National Audit Project Working Group. A national census of central neuraxial block in the UK: results of the snapshot phase of the Third National Audit Project of the Royal College of Anaesthetists. Anaesthesia. 2008;63(2):143-6.
2. Catterall W, Mackie, K. Anestésicos locales. En: Goodman and Gilman. Las bases farmacológicas de la terapéutica.11na ed. México: Mc Graw-Hill. Interamericana; 2006. p. 353-71.
3. Duarte LT, Fernandes M do C, Costa VV, Saraiva RA. The incidence of postoperative respiratory depression in patients undergoing intravenous or epidural analgesia with opioids. Rev Bras Anestesiol. 2009;59(4):409-20.
4. Mirrin KR, Rosen M. Medición del dolor. En: Swith G BG. Dolor Agudo. La Habana: Ciencias Médicas; 2007. p.111-40.
5. Roy JD, Girard M, Drolet P. Intrathecal Meperidine Decreases Shivering During Cesarean Delivery Under Spinal Anesthesia. Anesth Analg. 2004;98(1):230-4.
6. Datta S, Kodali BS, Segal S, editors.. Non-delivery obstetric procedures. En: .Obstetric Anesthesia Handbook. 5th. ed. New York: Springer Science; 2010. p. 357-67.
7. Kafle SK. Intrathecal meperidine for elective Caesarean section: a comparison with lidocaine. Can J Anaesth. 1993;40(8):718-21.
8. A comparison of the haemodynamic effects of intrathecal meperidine, meperidine-bupivacaine mixture and hyperbaric bupivacaine. Can J Anaesth. 1996;43(1):23-9.
9. Armstrong SC, Wynn GH, Sandson NB. Pharmacokinetic drug interactions of synthetic opiate analgesics. Psychosomatics. 2009;50(2):169-76.
10. Bamber J. Anaesthetist provided labour analgesia. Curr Anaesth Crit Care. 2006;17(3-4):131-41.
11. Inipavudu B, Mitterschiffthaler G, Hasibeder WR, Dünser MW. Spinal versus epidural anesthesia for vesicovaginal fistula repair surgery in a rural sub-Saharan African setting. J Clin Anesth. 2007;19(6):444-7.
12. Khan ZH, Zanjani AP, Makarem J, Samadi S. Antishivering effects of two different doses of intrathecal meperidine in caesarean section: a prospective randomised blinded study. Eur J Anaesthesiol. 2011;28(3):202-6.
13. Roofthooft E, Van de Velde M. Low-dose spinal anaesthesia for Caesarean section to prevent spinal-induced hypotension. Curr Opin Anaesthesiol. 2008;21(3):259-62.
14. Bakhsha F, Behnampour N. Saddle Block Anaesthesia with Meperidine for Perineal Surgery. J Clin Diagnos Res. 2010;4(1):2010-6.
15. Yu SC, Ngan-Kee WD, Kwan ASK. Addition of meperidine to bupivacaine for spinal anaesthesia for caesarean section. Br J Anaesth. 2002;88(3):379-83.
16. Evans L, Adekanye O. Ultra-low dose combined spinal-epidural anaesthesia. Int J Obstet Anesth. 2007;16(4):387-8.
17. Chun DH, Kil HK, Kim HJ, Park C, Chung KH. Intrathecal meperidine reduces intraoperative shivering during transurethral prostatectomy in elderly patients. Korean J Anesthesiol. 2010;59(6):389-93.
18. Atalay C, Aksoy M, Aksoy AN, Dogan N, Kürsad H. Combining intrathecal bupivacaine and meperidine during caesarean section to prevent spinal anaesthesia-induced hypotension and other side-effects. J Int Med Res. 2010;38(5):1626-36.
19. Weissman A, Torkhov O, Weissman AI, Drugan A. The effects of meperidine and epidural analgesia in labor on maternal heart rate variability. Int J Obstet Anesth. 2009;18(2):118-24.
20. Lorenzo Barrios LM, González Pérez SF. Anestesia intratecal hiperbárica. Petidina vs bupivacaína. Gaceta Médica Espirituana [Internet]. 2007 [citado 12 Feb 2010];9(1):[aprox. 4 p.]. Disponible en: http://bvs.sld.cu/revistas/gme/pub/vol.9.(1)_15/p15.html
21. Gurrieri C, Weingarten TN, Martin DP, Babovic N, Narr BJ, Sprung J, et al. Allergic Reactions During Anesthesia at a Large United States Referral Center. Anesth Analg. 2011 ;113(5):1202-12. Epub 2011 Aug 24.
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