Teratogenic effects of some drugs that can cause congenital heart disease and other abnormalities

Authors

  • Judith Cuba Marrero Universidad de Ciencias Médicas de Santiago de Cuba
  • Yanet Jordán Pita Universidad de Ciencias Médicas de Santiago de Cuba
  • Rosa E. Navarro Alemán Universidad de Ciencias Médicas de Santiago de Cuba
  • Lissett Batista Santos Universidad de Ciencias Médicas de Santiago de Cuba
  • Ileana González Palomo Universidad de Ciencias Médicas de Santiago de Cuba

Keywords:

pregnancy, drug utilization, congenital abnormalities

Abstract

Many of the malformations or abnormalities of anatomical or functional character provoked in the fetus are due to drug use by the mother during gestation. These disorders can be detected during intrauterine life, immediately after birth or at times, many years later, but they are generally diagnosed early and in certain circumstances they can compromise the life of the newborn. The main teratogenic effects of some drugs that can predispose to heart diseases and other congenital abnormalities are set out in this article in a general way.  The environment of a pregnant woman is loaded with aggressive substances for the future product of gestation. The majority of the most relevant malformations are produced during the teratogenic period, which comprises weeks third to eigth of gestation. Secondary prevention measures are based on prenatal diagnosis and genetic counseling.

Downloads

Download data is not yet available.

References

1. Hamilton WJ, Mossman HW. Embriología Humana, desarrollo prenatal de la forma y la función. 4ta ed. Buenos Aires: Inter-Médica; 1973. p. 204-17.

2. Langman J, Sadler TW. Embriología Medica con orientación clínica. 8va ed.. Argentina: Médica Panamericana; 2004. p. 116-22.

3. Dovales C. Rossel W, Álvarez I. Morfofisiología Humana I. La Habana: Ecimed; 2002.

4. López Castellano A, Moreno Royo L, Villagrasa SV. Manual de Farmacología. España: Elsevier; 2005. p. 114-7.

5. Achong Ley M, Cuesta Campos ER, Fernández de Landax M, Guía Gómez M, Levi Rodríguez M, Morón Rodríguez FJ, et al. Manual de Farmacología. La Habana: Minsap; 1988.

6. van Gelder MM, van Rooij IA, Miller RK, Zielhuis GA, de Jong-van den Berg LT, Roeleveld N. Teratogenic mechanisms of medical drugs. Hum Reprod Update. 2010;16(4):378-94.

7. Alonso RM, Cejas A, Rodríguez A, Serrat I. Posibles efectos teratogénicos de la medicación materna sobre el feto. Rev Cubana Med Gen Integr. 1987;3(3):21-6.

8. García JC, Vergel G, Zapata A. Embarazo y medicamentos en un área de salud. Rev Cubana Med Gen Integr [Internet]. 1999 [citado 13 Feb 2012]; 5(3):[aprox. 3 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-21251999000300001&lng=es.

9. Cruz M, Bosch J. Aspectos básicos. En: Atlas de síndromes pediátricos. 1ra. ed. Barcelona: Espaxs; 1998. p.15-30.

10. Emery AE, Mueller RF. Principios de genética médica. 6ta. ed. Madrid: Churchill Livingstone; 1992.

11. Medline Plus. Desarrollo fetal [Internet]. USA: U.S. National Library of Medicine; 2001 [citado 10 Ene 2012]. Disponible en: http://www.pcs.adam.com/ency/article/002398.htm

12. Mueller RF, Young ID. Genética y anomalías congénitas. En: Emery´s genética médica. 10ma. ed. Madrid: Marbán Libros; 2001. p. 223-34.

13. Dyce E, Chikuy M. Registro, incidencia y diagnóstico prenatal de las malformaciones congénitas mayores más severas. Rev Cubana Med Gen Integr. 1999;15(4):403-8.

14. Elhatton P. Farmacodivulgación. Rev Cubana Farm [Internet]. 2003 [citado 5 Ene 2012];37(2):[aprox. 4 p.]. Disponible en: http://bvs.sld.cu/revistas/far/vol37_2_03/far10203.htm

15. Perinatology.com. Drugs in pregnancy and breastfeeding [Internet]. 2009 [citado 5 Ene 2012]. Disponible en: http://www.perinatology.com/exposures/druglist.htm

Downloads

Published

2012-06-01

How to Cite

1.
Cuba Marrero J, Jordán Pita Y, Navarro Alemán RE, Batista Santos L, González Palomo I. Teratogenic effects of some drugs that can cause congenital heart disease and other abnormalities. CorSalud [Internet]. 2012 Jun. 1 [cited 2025 Oct. 2];4(2):124-9. Available from: https://revcorsalud.sld.cu/index.php/cors/article/view/1214

Issue

Vol. 4 No. 2 (2012)

Section

SPECIAL ARTICLES

Categories

License

Copyright (c) 2012 CorSalud

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.