Carbamazepine and cardiac conduction disorders: A case series
Abstract
Carbamazepine is an antiepileptic drug chemically related to tricyclic antidepressants. In therapeutic doses, it is not arrhythmogenic, but when toxic values are reached, it produces blockage of sodium channels, which favors the appearance of cardiac arrhythmias; sometimes it can lead to blockages of the cardiac conduction system. We present a series of four patients who were admitted with cardiac conduction disorders and were taking carbamazepine at the time of admission. All were hypertensive, 75% were women, and three of them had used the drug for a period of more than one year. The most frequent reason for admission was decay, requiring permanent pacemaker implantation, and one patient died after using carbamazepine again (defined causality). The remaining three had a possible causality with the consumption of this drug.Downloads
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