ST alternans induced by propafenone. Use-dependence of heart rate phenomenon demonstrated in clinical practice

Authors

  • Ginner O. Rizo Rivera

Abstract

ST alternans reflects changes in action potential duration with increased electrical heterogeneity proportional to the alternation intensity. Although the mechanisms of ST and T alternans are still largely unknown, four mechanisms have been proposed: a) calcium overload, b) effect of chemicals from sustained ischemia, c) stimulation of the 5-HTreceptor and d) inhomogeneous blockade of sodium channels. Propafenone is a class IC sodium channel blocker, frequently used in the pharmacological cardioversion of atrial fibrillation, and has a use-dependence of heart rate phenomenon that can induce a Brugada pattern and electrical alternans. In this article, a clinical case demonstrating these two phenomena is presented.

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Published

2014-07-04

How to Cite

1.
Rizo Rivera GO. ST alternans induced by propafenone. Use-dependence of heart rate phenomenon demonstrated in clinical practice. CorSalud [Internet]. 2014 Jul. 4 [cited 2025 Dec. 16];6(3):266-70. Available from: https://revcorsalud.sld.cu/index.php/cors/article/view/163

Issue

Vol. 6 No. 3 (2014)

Section

CASE REPORTS

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