Carotid intima-media thickness at different locations: Association to coronary heart disease in patients with heart valve disease

Authors

  • Joanna de Zayas Galguera Centro de Investigaciones Médico-Quirúrgicas - CIMEQ. La Habana, Cuba.
  • Aylen Pérez Barreda Centro de Investigaciones Médico-Quirúrgicas - CIMEQ. La Habana, Cuba.
  • Francisco Vázquez Castro Centro de Investigaciones Médico-Quirúrgicas - CIMEQ. La Habana, Cuba.
  • Ronald Aroche Aportela Centro de Investigaciones Médico-Quirúrgicas - CIMEQ. La Habana, Cuba.
  • Katia Ravelo Llanes Centro de Investigaciones Médico-Quirúrgicas - CIMEQ. La Habana, Cuba.
  • Myder Hernández Navas Centro de Investigaciones Médico-Quirúrgicas - CIMEQ. La Habana, Cuba.

Abstract

Introduction: The atherosclerosis is a generalized disease of the arterial wall. The carotid intima-media thickness (CIMT) has shown an association with cardiovascular risk factors and the prevalence of cardiovascular disease. The carotid ultrasound protocols differ considerably from one another.

Objective: To compare the value of the CIMT measured in several anatomical locations for the diagnosis of significant coronary disease.

Method: A total of 62 patients scheduled for valve replacement surgery with previous conventional coronary angiography (invasive) were studied. Before the surgery, the measurement of the CIMT was made in the common carotid artery (CCA), the bulb and in the internal carotid artery (ICA) through ultrasonography. The association among each of these variables, as well as the sensitivity, specificity and positive and negative predictive values were determined.

Results: Only 9 of the 62 patients studied had significant coronary lesions. It was observed that for values of similar sensitivity and specificity in the carotid segments studied, a higher cut-off value of CIMT was required in the bulb (0.87 mm) and even more in the ICA (0.98 mm), in relation to the CCA (0.71 mm), thus, the latter represents the method with the highest diagnostic value in the patients studied.

Conclusions: The group of patients with significant coronary lesions showed values of CIMT in each of the explored locations greater than the group without coronary lesions. The CCA was the place where the best visualization of the CIMT was obtained, and where acceptable validity parameters were achieved, as well as a good correlation with the coronary atherosclerosis of these patients.

Downloads

Download data is not yet available.

References

1. Valenzuela A, Morgado N. Breve historia de la relación entre el colesterol y las enfermedades cardiovasculares. RevChilNutr. 2006;33(2):130-4.

2. Genest J, McPherson R, Frohlich J, Anderson T, Campbell N, Carpentier A, et al. 2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult - 2009 recommendations. Can J Cardiol. 2009;25(10):567-79.

3. Reiner Z, Catapano AL, De Backer G, Graham I, Taskinen MR, Wiklund O, et al. ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J. 2011;32(14):1769-818.

4. Ministerio de Salud Pública. Anuario Estadístico de Salud 2011. La Habana: Dirección Nacional de Registros Médicos y Estadísticas de Salud; 2012.

5. Llerena-Rojas LR, Peix-González A, Valiente-Mustelier J. Técnicas de imagen no invasivas en la valoración y la prevención de la enfermedad coronaria. Rev Esp Cardiol Supl. 2011;11(E):36-44.

6. Nambi V, Chambless L, Folsom AR, He M, Hu Y, Mosley T, et al. Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC (Atherosclerosis Risk In Communities) study. J Am Coll Cardiol. 2010;55(15):1600-7.

7. LahozC, Mostaza JM. La aterosclerosis como enfermedad sistémica. Rev Esp Cardiol. 2007;60(2):184-95.

8. Velasco del Castillo S, Aguilar Torres R, Paré Bardera JC. Actualización en técnicas de imagen cardiaca: ecocardiografía, resonancia magnética en cardiología y tomografía computarizada con multidetectores. Rev Esp Cardiol. 2009;62(Supl1):129-50.

9. Folsom AR, Kronmal RA, Detrano RC, O'Leary DH, Bild DE, Bluemke DA, et al. Coronary artery calcification compared with carotid intima-media thickness in the prediction of cardiovascular disease incidence: the Multi-Ethnic Study of Atherosclerosis (MESA).Arch Intern Med. 2008;168(12):1333-9.

10. Polak JF, Pencina MJ,Pencina KM, O'Donnell CJ, Wolf PA, D'Agostino RB. Carotid-wall intima-media thickness and cardiovascular events. N Engl J Med. 2011;365(3):213-21.

11. Chain S, Luciardi HL, Feldman G, Valberdi A. El espesor íntima-media carotídeo, un marcador de ateroesclerosis subclínica y riesgo cardiovascular. Importancia de su valoración y dificultades en su interpretación. Rev Fed Arg Cardiol. 2005;34(3):392-402.

12. Simon A, Gariepy J, Chironi G, Megnien JL, Levenson J. Intima-media thickness: A new tool for diagnosis and treatment of cardiovascular risk. J Hypertens. 2002;20(2):159-69.

13. Hulthe J, Wikstrand J, Emanuelsson H, Wiklund O, de Feyter PJ, Wendelhag I. Atherosclerotic changes in the carotid artery bulb as measured by B-mode ultrasound are associated with the extent of coronary atherosclerosis. Stroke. 1997;28(6):1189-94.

14. Mack WJ, Selzer RH, Hodis HN, Erickson JK, Liu CR, Liu CH, et al. One-year reduction and longitudinal analysis of carotid intima-media thickness associated with colestipol/niacin therapy. Stroke. 1993;24(12):1779-83.

15. Tang R, Hennig M, Thomasson B, Scherz R, Ravinetto R, Catalini R, et al. Baseline reproducibility of B-mode ultrasonic measurement of carotid artery intima-media thickness: the European Lacidipine Study on Atherosclerosis (ELSA). J Hypertens. 2000;18(2):197-201.

16. Nafeh M, HernándezR, Carballo N, Villar A, Guevara L, Chaos N, et al. Resultados de la revascularización coronaria en el Cardiocentro del Hospital «Hermanos Ameijeiras», en un período de 20 años. Rev Cubana Cir [Internet]. 2011 [citado 15 Oct 2017];50(1):54-72.Disponible en: http://scielo.sld.cu/pdf/cir/v50n1/cir05111.pdf

17. Iscan HZ, Kandemir O, Gol MK, Saritas A, Tasdemir O. Coronary reoperations without the use of cardiopulmonary bypass. Cardiovasc Surg. 2003;11(2):155-8.

18. Gómez Doblas JJ, Jiménez Navarro M, Rodríguez Bailón I, Alonso Briales JH, Hernández García JM, Montiel Trujillo A, et al. Coronariografía preoperatoria en pacientes valvulares. Análisis de probabilidad de lesión coronaria. Rev Esp Cardiol. 1998;51(9):756-61.

19. Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, Guyton RA, et al. 2014 AHA/ACC Guideline for the management of patients with valvular heart disease: Executive summary: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.Circulation. 2014;129(23):2440-92.

20. Coskun U, Yildiz A, Esen OB, Baskurt M, Cakar MA, Kilickesmez KO, et al.Relationship between carotid intima-media thickness and coronary angiographic findings: A prospective study. Cardiovasc Ultrasound [Internet]. 2009 [citado 10 Oct 2017];7:59. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809045/

21. Carreras F, Borrás X, Pons G, Abadal ML, Auge J, Crexells C,et al. Prevalence of coronary artery disease in chronic valvular heart disease. Eur Heart J. 1987;8(Supl2):142 [Resumen].

22. Torrents A, Esplugas E, Jara F, MauriJ. ¿Ha variado desde 1980 la indicación de coronariografía preoperatoria en pacientes valvulares? Estudio prospectivo de 300 nuevos casos consecutivos. Rev Esp Cardiol. 1988;41(10):586-9.

23. Muñoz San José JC,de la Fuente Galán L, Garcimartin Cerrón I, de la Torre CarpenterM, Bermejo García J, Alonso Martín J, et al. Coronariografía preoperatoria en pacientes valvulares. Criterios de indicación en una determinada población. Rev Esp Cardiol. 1997;50(7):467-73.

24. Fournier JA, Sánchez-González A, Cortacero JA, Martínez A. Estudio angiográfico prospectivo de la enfermedad arterial coronaria en pacientes con patología valvular crónica severa. Rev Esp Cardiol. 1988;41(8):462-6.

25. Lorenz MW, von Kegler S, Steinmetz H, Markus HS, Sitzer M. Carotid intima-media thickening indicates a higher vascular risk across a wide age range: Prospective data from the Carotid Atherosclerosis Progression Study (CAPS). Stroke. 2006;37(1):87-92.

26. Naghavi M, Falk E, Hecht HS, Jamieson MJ, Kaul S, Berman D, et al. From vulnerable plaque to vulnerable patient – Part III: Executive summary of the Screening for Heart Attack Prevention and Education (SHAPE) Task Force report. Am J Cardiol. 2006;98(2A):2H-15H.

27. García Fernández R, García Pérez-Velazco J, Concepción Milián A, Curbelo Cuevas MA, García Barreto D. Diagnóstico incruento de la aterosclerosis por ultrasonido. Estructura vascular grosor íntima-media de la pared arterial. Rev Cubana Med [Internet]. 2003 [citado 15 Oct 2017];42(3). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75232003000300008

28. Johnsen SH, Mathiesen EB. Carotid plaque compared with intima-media thickness as a predictor of coronary and cerebrovascular disease. Curr Cardiol Rep. 2009;11(1):21-7.

Downloads

Published

2018-04-19

How to Cite

1.
de Zayas Galguera J, Pérez Barreda A, Vázquez Castro F, Aroche Aportela R, Ravelo Llanes K, Hernández Navas M. Carotid intima-media thickness at different locations: Association to coronary heart disease in patients with heart valve disease. CorSalud [Internet]. 2018 Apr. 19 [cited 2025 Jun. 21];10(2):113-21. Available from: https://revcorsalud.sld.cu/index.php/cors/article/view/237

Issue

Vol. 10 No. 2 (2018)

Section

ORIGINAL ARTICLES

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.