Chemotherapy-induced cardiotoxicity
Abstract
Cancer is a major public health problem in the world. Chemotherapy is indicated in several phases of the antineoplastic treatment, either as neoadjuvant, adjuvant or palliative therapy. One of the most worrisome side effects generated by chemotherapy is cardiotoxicity, and one of the main symptoms is heart failure, secondary to damage to the myocardium due to the direct and indirect toxicity of antineoplastic therapies. The objective of this article is to review the state of the art of the chemotherapy-induced cardiotoxicity, as well as to synthesize the different cardiotoxic effects, cardiotoxic mechanisms and methods that have been developed for its diagnosis and prevention.Downloads
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1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65(1):5-29.
2. Ministerio de Salud Pública. Anuario Estadístico de Salud 2016. La Habana: Dirección Nacional de Registros Médicos y Estadísticas de Salud; 2017.
3. DeSantis CE, Lin CC, Mariotto AB, Siegel RL, Stein KD, Kramer JL, et al. Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin. 2014;64(4):252-71.
4. Plana JC, Galderisi M, Barac A, Ewer MS, Ky B, Scherrer-Crosbie M, et al. Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2014;27(9):911-39.
5. Lal H, Kolaja KL, Force T. Cancer genetics and the cardiotoxicity of the therapeutics. J Am Coll Cardiol. 2013;61(3):267-74.
6. Yusuf SW, Sami S, Daher IN. Radiation-induced heart disease: A clinical update. Cardiol Res Pract [Internet]. 2011 [citado 15 Oct 2017];2011:317659. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051159/pdf/CRP2011-317659.pdf
7. Carver JR, Shapiro CL, Ng A, Jacobs L, Schwartz C, Virgo KS, et al. American Society of Clinical Oncology clinical evidence review on the ongoing care of adult cancer survivors: Cardiac and pulmonary late effects. J Clin Oncol. 2007;25(25):3991-4008.
8. Ruiz Mori E, Ayala Bustamante L, Burgos Bustamante J. Insuficiencia cardíaca por quimioterapia. Rev Soc Peruana Med Interna. 2016;29(2):59-64.
9. Perrino C, Schiattarella GG, Magliulo F, Ilardi F, Carotenuto G, Gargiulo G, et al. Cardiac side effects of chemotherapy: State of art and strategies for a correct management. Curr Vasc Pharmacol. 2014;12(1):106-16.
10. Bloom M, Hamo CE, Cardinale D, Ky B, Nohria A, Baer L, et al. Cancer Therapy-Related Cardiac Dysfunction and Heart Failure: Part 1: Definitions, Pathophysiology, Risk Factors, and Imaging. Circ Heart Fail [Internet]. 2016 [citado 15 Oct 2017];9(1):e002661. Disponible en: http://circheartfailure.ahajournals.org/content/9/1/e002661.long
11. Wise J. Adult survivors of childhood cancer are at high risk of cardiac abnormalities, study finds. BMJ [Internet]. 2016 [citado 15 Oct 2017];352:h7026. Disponible en: https://search.proquest.com/openview/d6b604e490d36b922a0723b4d3bcebe8/1.pdf?pq-origsite=gscholar&cbl=2043523
12. Velásquez CA, González M, Berrouet MC, Jaramillo N. Cardiotoxicidad inducida por la quimioterapia desde las bases moleculares hasta la perspectiva clínica. Rev Colomb Cardiol. 2016;23(2):104-11.
13. Meza-Cejudo S. Cardiotoxicidad por quimioterapia; implicaciones anestésicas. Rev Mex Anestesiol. 2017;40(Supl 1):S18-S20.
14. Prado A. Miocardiopatía producida por antineoplásicos. Un nuevo desafío para los cardiólogos. Rev Fed Arg Cardiol. 2016;45(4):164-7.
15. Jiménez-Cotes EA, Meyer-Martínez WS, Gallego-González D. Biomarcadores en la detección temprana de cardiotoxicidad inducida por quimioterapia; estado actual. Arch Med (Manizales). 2015;15(1):126-37.
16. López-Fernández T, Martín García A, Santaballa Beltrán A, Montero Luis Á, García Sanz R, Mazón Ramos P, et al. Cardio-Onco-Hematología en la práctica clínica. Documento de consenso y recomendaciones. Rev Esp Cardiol. 2017;70(6):474-86.
17. Navarro-Ulloa OD, Barranco-Camargo LA, Jurado-López SP, Zabala-Carballo CI, Giraldo-Peniche LE. Muerte súbita debida a cardiotoxicidad aguda inducida por antraciclinas. Rev Colomb Cardiol [Internet]. 2018 [citado 02 Ene 2018];25(1):80.e1-7. Disponible en: http://www.elsevier.es/es-revista-revista-colombiana-cardiologia-203-articulo-muerte-subita-debida-cardiotoxicidad-aguda-S0120563317301353
18. Klaassen CD, editor. Casarett and Doull’s Toxicology: The basic science of poisons. 8ª ed. New York: McGraw-Hill Education; 2013.
19. Ritter J, Flower R, Henderson G, Rang H. Rang & Dale's Pharmacology. Edinburgh: Churchill Livingstone; 2015.
20. Martins KF, Messias AD, LeiteI FL, Duek E. Preparation and characterization of paclitaxel-loaded PLDLA microspheres. Materials Research. 2014;17(3):650-6.
21. Lax J, Piñeiro D, Falconi M, Agüero R, Barugel M, Bermann, et al. Consenso de diagnóstico, prevención y tratamiento de la cardiotoxicidad por tratamiento médico del cáncer. Rev Argent Cardiol [Internet]. 2013. [citado 02 Ene 2018];81(Supl. 5):1-64. Disponible en: https://www.sac.org.ar/wp-content/uploads/2014/04/Consenso-Cardiotoxicidad.pdf
22. Schlitt A, Jordan K, Vordermark D, Schwamborn J, Langer T, Thomssen C. Cardiotoxicity and oncological treatments. Dtsch Arztebl Int. 2014;111(10):161-8.
23. López-Velarde Peña T, López-Velarde Badager P. Prevención y tratamiento de cardiotoxicidad en pacientes con cáncer. An Med (Mex). 2014;59(1):54-60.
24. Reborido N, Parma G, Noria S, Schiavone A, Bonelli A, Lluberas R. Strain bidimensional para detección precoz de disfunción sistólica del ventrículo izquierdo inducida por agentes quimioterápicos. Rev Urug Cardiol. 2016;31(2):266-76.
25. Espinola Zavaleta N, Lupi Herrera E. El papel del ecocardiograma en la valoración de la cardiotoxicidad por quimioterapia. An Med (Mex). 2015;60(3):199-205.
26. Armenian SH, Lacchetti C, Barac A, Carver J, Constine LS, Denduluri N, et al. Prevention and monitoring of cardiac dysfunction in survivors of adult cancers: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. 2017;35(8):893-911.
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