Changes in ventricular depolarization and repolarization in the clinical follow-up of a patient with Brugada syndrome

Authors

  • Marcelo V. Puga Bravo
  • Jesús A. Castro Hevia
  • Yisel Gallardo Medina

Abstract

We present the case of a 55-year-old woman with syncopal episodes and a diagnosis of Brugada syndrome, who spontaneously presented the convex pattern. She received an implantable cardioverter-defibrillator and had a ventricular fibrillation event in the clinical follow-up (106 months). Over this time, 13 electrocardiograms were performed, all of them showing the convex pattern. Moreover, significant variability was observed in wave morphology and electrocardiographic measurements related to depolarization and ventricular repolarization.

Downloads

Download data is not yet available.

References

1. Antzelevitch C, Yan GX. J-wave syndromes: Brugada and early repolarization syndromes. Heart Rhythm. 2015;12(8):1852-66.

2. Priori SG, Blomström-Lundqvist C, Mazzanti A, Blom N, Borggrefe M, Camm J, et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC).Eur Heart J. 2015;36(41):2793-2867.

3. Priori SG, Wilde AA, Horie M, Cho Y, Behr ER, Berul C, et al. Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes. Europace. 2013;15(10):1389-406.

4. Priori SG, Napolitano C, Gasparini M, Pappone C, Della Bella P, Giordano U, et al. Natural history of Brugada syndrome: insights for risk stratification and management. Circulation. 2002;105(11):1342-7.

5. Brugada J, Brugada R, Brugada P. Determinants of sudden cardiac death in individuals with the electrocardiographic pattern of Brugada syndrome and no previous cardiac arrest. Circulation. 2003;108(25):3092-6.

6. Naseef A, Behr ER, Batchvarov VN. Electrocardiographic methods for diagnosis and risk stratification in the Brugada syndrome. J Saudi Heart Assoc. 2015;27(2):96-108.

7. Adler A, Rosso R, Chorin E, Havakuk O, Antzelevitch C, Viskin S. Risk stratification in Brugada syndrome: Clinical characteristics, electrocardiographic parameters, and auxiliary testing. Heart Rhythm. 2016;13(1):299-310.

8. Wilde AA, Antzelevitch C, Borggrefe M, Brugada J, Brugada R, Brugada P, et al. Proposed diagnostic criteria for the Brugada syndrome: consensus report. Circulation. 2002;106(19):2514-9.

9. Antzelevich C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D, et al. Brugada syndrome: Report of the second consensus conference. Circulation. 2005;111(5):659-70.

10. Pitzalis MV, Anaclerio M, Iacoviello M, Forleo C, Guida P, Troccoli R, et al. QT-interval prolongation in right precordial leads: an additional electrocardiographic hallmark of Brugada syndrome. J Am Coll Cardiol. 2003;42(9):1632-7.

11. Castro Hevia J, Antzelevitch C, Tornés Bárzaga F, Dorantes Sánchez M, Dorticós Balea F, Zayas Molina R, et al. Tpeak-Tend and Tpeak-Tend dispersion as risk factors for ventricular tachycardia/ventricular fibrillation in patients with the Brugada syndrome. J Am Coll Cardiol. 2006;47(9):1828-34.

12. Maury P, Sacher F, Gourraud JB, Pasquié JL, Raczka F, Bongard V, et al. Increased Tpeak-Tend interval is highly and independently related to arrhythmic events in Brugada syndrome. Heart Rhythm. 2015;12(12):2469-76.

13. Letsas KP, Weber R, Astheimer K, Kalusche D, Arentz T. Tpeak-Tend interval and Tpeak-Tend/QT ratio as markers of ventricular tachycardia inducibility in subjects with Brugada ECG phenotype. Europace. 2010;12(2):271-4.

14. Nakano Y, Shimizu W, Ogi H, Suenari K, Oda N, Makita Y, et al. A spontaneous Type 1 electrocardiogram pattern in lead V2 is an independent predictor of ventricular fibrillation in Brugada syndrome. Europace. 2010;12(3):410-6.

15. Okamura H, Kamakura T, Morita H, Tokioka K, Nakajima I, Wada M, et al. Risk stratification in patients with Brugada syndrome without previous cardiac arrest – prognostic value of combined risk factors. Circ J. 2015;79(2):310-7.

Downloads

Published

2018-07-23

How to Cite

1.
Puga Bravo MV, Castro Hevia JA, Gallardo Medina Y. Changes in ventricular depolarization and repolarization in the clinical follow-up of a patient with Brugada syndrome. CorSalud [Internet]. 2018 Jul. 23 [cited 2025 Jul. 1];10(3):261-5. Available from: https://revcorsalud.sld.cu/index.php/cors/article/view/362

Issue

Vol. 10 No. 3 (2018)

Section

CASE REPORTS

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.