Early atherosclerotic signs in middle-aged women with a history of pre-eclampsia
Abstract
Introduction: In our country, cardiovascular diseases are the leading cause of death among women.
Objective: To identify early atherosclerotic signs in middle aged women with a history of pre-eclampsia.
Method: An observational descriptive study was carried out with 108 women aged 45-59 years old, at the Policlínico Docente Chiqui Gómez Lubián, in Santa Clara (Cuba), over the years 2017 and 2018. The study group was made up of 54 women who had a history of pre-eclampsia in the last decade while the control group comprised the same number of women with no history of pre-eclampsia.
Results: The most prevalent risk factor in the total number of women studied was the combination of overweight and obesity (75%); this subgroup comprised 98.1% of those with a history of pre-eclampsia. It was followed in frequency by hypercholesterolemia (71.3%), high blood pressure (54.6%), smoking (51.8%) and diabetes mellitus (38.9%). The 92.6% of women with a history of pre-eclampsia were hypertensive and all had an abdominal circumference ≥ 88 cm. Furthermore, all those with moderate, high or very high cardiovascular risk had a history of pre-eclampsia, and of the total number of women with low cardiovascular risk, only 22 (28.9%) had such a background; as the rest (71.1%) accounted for the total number of women without pre-eclampsia.
Conclusions: Early atherosclerotic signs: obesity, abdominal circumference greater than 88 cm and high blood pressure, as well as atherogenic risk factors associated with moderate, high and very high cardiovascular risk predominated in women with pre-eclampsia.Downloads
References
1. Ministerio de Salud Pública. Anuario Estadístico de Salud 2017. La Habana: Dirección de Registros Médicos y Estadísticas de Salud; 2018.
2. León Regal ML, Benet Rodríguez M, Brito Pérez de Corcho Y, González Otero LH, de Armas García JO, Miranda Alvarado L. La hiperreactividad cardiovascular y su asociación con factores de riesgo cardiovasculares. Rev Finlay [Internet]. 2015 [citado 4 Jul 2019];5(4):228-41. Disponible en: http://revfinlay.sld.cu/index.php/finlay/article/view/377/1445
3. Yong J, Lin D, Tan XR. Primary prevention of cardiovascular disease in older adults in China. World J Clin Cases. 2017;5(9):349-359.
4. Llapur Milián R, González Sánchez R. La enfermedad cardiovascular aterosclerótica desde la niñez a la adultez. Rev Cuban Pediatr [Internet]. 2017 [Citado 28 Jun 2019];89(3). Disponible en: http://www.revpediatria.sld.cu/index.php/ped/article/view/389/130
5. Miguel Soca PE, Peña González M. Síndrome metabólico, hipertensión arterial y adiposidad. MEDISAN [Internet]. 2017 [citado 5 Jul 2019];21(2):141-3. Disponible en: http://www.medisan.sld.cu/index.php/san/article/view/1008/pdf
6. Valdés Ramos E, Castillo Oliva Y, Valdés Bencosme E. Estimación del riesgo cardiovascular global en mujeres diabéticas de edad mediana. Rev Cuba Endocrinol [Internet]. 2017 [citado 5 Jul 2019];28(3). Disponible en: http://www.revendocrinologia.sld.cu/index.php/endocrinologia/article/view/88/76
7. Suárez González JA y Gutiérrez Machado M. Caracterización del riesgo cardiometabólico en mujeres de edad mediana con antecedentes de preeclampsia en la última década. CorSalud [Internet]. 2019 [citado 7 Jul 2019];11(1):30-6. Disponible en: http://www.revcorsalud.sld.cu/index.php/cors/article/view/407/814
8. Naranjo Domínguez AA, Padrón González AA, Arman Alessandini GE, Aroche Aportela R, Cabinda A. Señales aterogénicas tempranas en un área de salud del municipio Consolación del Sur. CorSalud [Internet]. 2014 [citado 7 Jul 2019];6(4):314-20. Disponible en: http://www.revcorsalud.sld.cu/index.php/cors/article/view/119/289
9. Lurbe E, Agabiti-Rosei E, Cruickshank JK, Dominiczak A, Erdine S, Hirth A, et al. 2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents. J Hypertens. 2016;34(10):1887-920.
10. Lugones Botell MA, Navarro Despaigne D, Fernández Britto-Rodríguez JE, Bacallao Gallestey J. Intensidad y evolución del síndrome climatérico y su relación con los factores de riesgo para aterosclerosis. Rev Cuban Obstet Ginecol [Internet]. 2017 [citado 8 Jul 2019];43(1): Disponible en: http://revginecobstetricia.sld.cu/index.php/gin/article/view/149/135
11. Pérez Piñero JS. Escala cubana para clasificar la intensidad del síndrome climatérico. Resultados de su aplicación en provincias seleccionadas 1999 – 2004 [Tesis Doctoral]. La Habana: Editorial Universitaria [Internet]; 2008 [citado 8 Jul 2019]. Disponible en: http://tesis.sld.cu/index.php?P=DownloadFile&Id=300
12. Organización Mundial de la Salud. Prevención de las enfermedades cardiovasculares: Guía de bolsillo para la estimación y el manejo del riesgo cardiovascular. Ginebra: OMS [Internet]; 2008 [citado 9 Jul 2019]. Disponible en: https://www.who.int/publications/list/PocketGL_spanish.pdf?ua=1
13. American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2019. Diabetes Care. 2019;42(Suppl 1):S13-S28.
14. Lohman TG, Roche AF, Martorell R, Eds. Anthropometric standarization reference manual. Abridged edition. Champaign, Illinois: Human Kinetic Books, 1988.
15. Mill-Ferreyra E, Cameno-Carrillo V, Saúl-Gordo H, Camí-Lavado MC. Estimación del porcentaje de grasa corporal en función del índice de masa corporal y perímetro abdominal: fórmula Palafolls. Semergen. 2019;45(2):101-8.
16. Pérez Caballero MD, León Álvarez JL, Dueñas Herrera A, Alfonzo Guerra JP, Navarro Despaigne DA, de la Noval García R, et al. Guía cubana de diagnóstico, evaluación y tratamiento de la hipertensión arterial. Rev Cuban Med [Internet]. 2017 [citado 9 Jul 2019];56(4):242-321. Disponible en: http://scielo.sld.cu/pdf/med/v56n4/med01417.pdf
17. Masson W, Siniawski D, Lobo M, Molinero G, Huerín M. Asociación entre la razón triglicéridos/colesterol HDL y ateromatosis carotídea en mujeres posmenopáusicas de mediana edad. Endocrinol Nutr. 2016;63(7):327-32.
18. American Diabetes Association. Standards of Medical Care in Diabetes – 2017. Diabetes Care. 2017;40(Supl 1):S1-S135.
19. James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014;311(5):507-20.
20. Oramas Hernández L, Lugones Botell M, Massip Nicot J. Sobrecarga de género asociada al riesgo cardiovascular en mujeres de edad mediana supuestamente sanas del policlínico “Mártires del Corynthia”. Rev Cuban Obstet Ginecol [Internet]. 2017 [citado 10 Jul 2019];43(3). Disponible en: http://revginecobstetricia.sld.cu/index.php/gin/article/view/237/180
21. Song SH. Early-onset type 2 diabetes: high lifetime risk for cardiovascular disease. Lancet Diabetes Endocrinol. 2016;4(2):87-8.
22. Huo X, Gao L, Guo L, Xu W, Wang W, Zhi X, et al. Risk of non-fatal cardiovascular diseases in early-onset versus late-onset type 2 diabetes in China: a cross-sectional study. Lancet Diabetes Endocrinol. 2016;4(2):115-24.
23. Bojar I, Gujski M, Raczkiewicz D, Łyszcz R, Owoc J, Walecka I. Estrogen receptor alpha polymorphisms, estradiol level, and occurrence of atherosclerosis risk factors in healthy postmenopausal women. Med Sci Monit. 2015;21:970-9.
24. Navarro Despaigne D, León Sánchez A, Roca Soler I. Calidad de vida en mujeres de edad mediana de La Habana. Rev Cuban Obstet Ginecol [Internet]. 2017 [citado 10 Jul 2019];43(2). Disponible en: http://revginecobstetricia.sld.cu/index.php/gin/article/view/137/145
25. Irecta Najera CA, Álvarez Gordillo GC. Mecanismos moleculares de la obesidad y el rol de las adipocinas en las enfermedades metabólicas. Rev Cuban Invest Bioméd [Internet]. 2016 [citado 11 Jul 2019];35(2):174-83. Disponible en: http://scielo.sld.cu/pdf/ibi/v35n2/ibi06216.pdf
26. Livingstone KM, Celis-Morales C, Papandonatos GD, Erar B, Florez JC, Jablonski KA, et al. FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials. BMJ [Internet]. 2016 [citado 11 Jul 2019];354:i4707. Disponible en: http://doi.org/10.1136/bmj.i4707
27. Anderson D, Seib C, McGuire A, Porter-Steele J. Decreasing menopausal symptoms in women undertaking a web-based multi-modal lifestyle intervention: The Women's Wellness Program. Maturitas. 2015;81(1):69-75.
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