Ventricular repolarization in cancer therapy

Authors

  • Margarita Dorantes Sánchez
  • Manuel Bazán Milián

Abstract

Ventricular depolarization and repolarization processes are discussed, including their differences and heterogeneity both in patients with a healthy/sick heart, a matter of ranges. Measurements expressing the characteristics of ventricular repolarization are analyzed: the QT interval and other even more reliable measurements such as the TPEAK-TEND interval, its dispersion and others. We emphasize on the existence of the long QT syndrome (and sign) and the three basic processes of arrhythmogenesis: heterogeneity, alternation and dispersion, with differences in action potentials in the three zones of the ventricular myocardium. The risk factors of long QT (common in this therapy) and ventricular arrhythmias (especially torsades de pointes, extremely rare in these cases) are highlighted. The need to assess clinical and electrical features, comorbidities, aggregate conflicts, and management of these patients is also discussed.

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Published

2019-04-06

How to Cite

1.
Dorantes Sánchez M, Bazán Milián M. Ventricular repolarization in cancer therapy. CorSalud [Internet]. 2019 Apr. 6 [cited 2025 Jul. 2];11(2):146-52. Available from: https://revcorsalud.sld.cu/index.php/cors/article/view/462

Issue

Vol. 11 No. 2 (2019)

Section

SPECIAL ARTICLES

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