Clinico-epidemiological characterization with a surgical approach of infective endocarditis in the central region of Cuba

Authors

  • Alain Allende González
  • Gustavo de J. Bermúdez Yera
  • Roger Mirabal Rodríguez
  • Yolepsis F. Quintero Fleites
  • Yoandy López de la Cruz
  • Ernesto Chaljub Bravo

Abstract

Introduction: Infective endocarditis has not decreased its incidence and mortality in the last 30 years.

Objective: To characterize patients operated on due to diagnosis of active infective endocarditis.

Methods: A retrospective, descriptive study was carried out, which included 109 patients with a diagnosis of this disease, who underwent surgery at Cardiocentro Ernesto Che Guevara (Cuba), from July 2010 to June 2018. The information was obtained from the medical records and the surgical report.

Results: Prosthetic valve infective endocarditis was diagnosed in 15 patients (13.8%), but the most frequent was the one related to intracardiac device colonization (51.4%), reason why the most used surgical procedure was the change of the electrical stimulation system. The main surgical indication was the uncontrolled infection in 63 cases (57.8%), followed by heart failure (38 patients; 34.9%) and in 67 cases (61.5%), the blood cultures were negative. The native valve replacement for a mechanical prosthetic valve was performed in 28 patients (25.7%), of which 15 (13.8%) were in mitral position. The replacement of a mechanical prosthetic valve for another with the same characteristics was carried out in 14 (12.8%) cases, 8 (7.3%) of them were mitral. Overall mortality was of 17.4%, more evident in those with left-side prosthetic valve endocarditis (7/15).

Conclusions: Male gender and age over 60 years old predominated, as well as the presence of vegetations on intracardiac devices, and negative blood cultures. The prosthetic valve endocarditis was significantly associated with mortality.

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References

1. Habib G, Hoen B, Tornos P, Thuny F, Prendergast B, Vilacosta I, et al. Guía de práctica clínica para prevención, diagnóstico y tratamiento de la endocarditis infecciosa (nueva versión 2009). Grupo de Trabajo de la Sociedad Europea de Cardiología (ESC) para Prevención, Diagnóstico y Tratamiento de la Endocarditis Infecciosa. En colaboración con la European Society of Clinical Microbiology and Infectious Diseases (ESCMID) y la International Society of Chemotherapy (ISC) for Infection and Cancer. Rev Esp Cardiol. 2009;62(12):1465.e1-e54.

2. Serra Valdés M. La endocarditis infecciosa sigue desafiando a la clínica moderna. Rev Cuban Med [Internet]. 2011 [citado 2019 Jul 3];50(3):302-10. Disponible en: http://scielo.sld.cu/pdf/med/v50n3/med08311.pdf

3. Baddour LM, Wilson WR, Bayer AS, Fowler VG, Tleyjeh IM, Rybak MJ, et al. Infective endocarditis in adults: Diagnosis, antimicrobial therapy, and management of complications: A scientific statement for healthcare professionals from the American Heart Association. Circulation. 2015;132(15):1435-86.

4. Cahill TJ, Prendergast BD. Infective endocarditis. Lancet. 2016;387(10021):882-93.

5. Cahill TJ, Baddour LM, Habib G, Hoen B, Salaun E, Pettersson GB, et al. Challenges in Infective Endocarditis. J Am Coll Cardiol. 2017;69(3):325-44.

6. Fernández-Hidalgo N, Tornos Mas P. Epidemiología de la endocarditis infecciosa en España en los últimos 20 años. Rev Esp Cardiol. 2013;66(9):728-33.

7. Avellana PM, García M, Swieszkowski S, Nacinovich F, Kazelian L, Spennato M, et al. Endocarditis infecciosa en la República Argentina. Resultados del estudio EIRA 3. Rev Argent Cardiol. 2018;86(1):20-8.

8. Francischetto O, Silva LA, Senna KM, Vasques MR, Barbosa GF, Weksler C, et al. Healthcare-associated infective endocarditis: a case series in a referral hospital from 2006 to 2011. Arq Bras Cardiol. 2014;103(4):292-8.

9. Saito C, Padilla M, Valle A, Castañeda E. Tratamiento quirúrgico de la endocarditis infecciosa en un hospital general: Indicaciones y morbi-mortalidad. Rev Med Hered. 2014;25(3):135-41.

10. Ramírez López MB, Pérez López HE, Calzada Fajardo A, Estévez Álvarez N, Llanes Echevarría J. Principales aspectos del tratamiento quirúrgico en pacientes con endocarditis infecciosa. Rev Cuban Cardiol [Internet]. 2014 [citado 2020 Jul 4];20(4):243-50. Disponible en: http://www.revcardiologia.sld.cu/index.php/revcardiologia/article/view/549/682

11. Perdomo García FJ, Martínez Muñiz JO, Torralbas Reverón FE, Machín Rodríguez JC, Martínez Rodríguez O. Endocarditis infecciosa: experiencia quirúrgica en el Cardiocentro de Santiago de Cuba. MEDISAN [Internet]. 2011 [citado 2020 Jul 6];15(6):736-44. Disponible en: http://scielo.sld.cu/pdf/san/v15n6/san03611.pdf

12. Al Abri SS, Zahedi FI, Kurup PJ, Al-Jardani AK, Beeching NJ. The epidemiology and outcomes of infective endocarditis in a tertiary care hospital in Oman. J Infect Public Health. 2014;7(5):400-6.

13. Eusse A, Atehortúa M, Vélez L, Bucheli V, Dallos C, Flores G, et al. Tratamiento quirúrgico de la endocarditis infecciosa. Rev Colomb Cardiol. 2014;21(1):52-7.

14. Watt G, Pachirat O, Baggett HC, Maloney SA, Lulitanond V, Raoult D, et al. Infective endocarditis in northeastern Thailand. Emerg Infect Dis. 2014;20(3):473-6.

15. Castillo JC, Anguita MP, Delgado M, Ruiz M, Mesa D, Romo E, et al. Características clínicas y pronóstico de la endocarditis infecciosa en la mujer. Rev Esp Cardiol. 2008;61(1):36-40.

16. Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, et al. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J. 2015;36(44):3075-128.

17. Oyonarte M, Montagna R, Braun S, Rojo P, Jara JL, Cereceda M, et al. Endocarditis infecciosa: características clínicas, complicaciones y mortalidad en 506 pacientes y factores pronósticos de sobrevida a 10 años (1998-2008). Estudio cooperativo nacional en endocarditis infecciosa en Chile (ECNEI-2). Rev Méd Chile. 2012;140(12):1517-28.

18. Sandoe JA, Barlow G, Chambers JB, Gammage M, Guleri A, Howard P, et al. Guidelines for the diagnosis, prevention and management of implantable cardiac electronic device infection. Report of a joint Working Party project on behalf of the British Society for Antimicrobial Chemotherapy (BSAC, host organization), British Heart Rhythm Society (BHRS), British Cardiovascular Society (BCS), British Heart Valve Society (BHVS) and British Society for Echocardiography (BSE). J Antimicrob Chemother. 2015;70(2):325-59.

19. Forteza A, Centeno J, Ospina V, Lunar IG, Sánchez V, Pérez E, et al. Outcomes in aortic and mitral valve replacement with intervalvular fibrous body reconstruction. Ann Thorac Surg. 2015;99(3):838-45.

20. Machado MN, Nakazone MA, Murad-Júnior JA, Maia LN. Surgical treatment for infective endocarditis and hospital mortality in a Brazilian single-center. Rev Bras Cir Cardiovasc. 2013;28(1):29-35.

Published

2020-04-18

How to Cite

1.
Allende González A, Bermúdez Yera G de J, Mirabal Rodríguez R, Quintero Fleites YF, López de la Cruz Y, Chaljub Bravo E. Clinico-epidemiological characterization with a surgical approach of infective endocarditis in the central region of Cuba. CorSalud [Internet]. 2020 Apr. 18 [cited 2025 Aug. 22];12(2):138-45. Available from: https://revcorsalud.sld.cu/index.php/cors/article/view/650

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Section

ORIGINAL ARTICLES