Global longitudinal strain value in the early detection of chemotherapy-induced cardiotoxicity

Authors

  • Saraí Torres González Hospital Abel Santamaría Cuadrado.
  • Sheila Hechavarria Pouymiró INSTITUTO CARDIOLOGIA Y CIRUGIA CARDIOVASCULAR LA HABANA http://orcid.org/0000-0002-9974-9876
  • José A. Fernández Cueto Hospital Abel Santamaría Cuadrado
  • Reinel Álvarez Plasencia ICCCV La Habana.
  • Santa C. González Corrales
  • Danet Milán Roca

Abstract

Introduction: Advances in early detection and treatment of cancer have significantly reduced mortality. The net result is the emergence of a cohort of patients whose survival is sufficient to evidence the side effects of the used therapies. Cardiotoxicity is the set of cardiovascular diseases resulting from onco-hematological treatments.

Objectives: To evaluate the role of global longitudinal strain in the early detection of cardiotoxicity in patients undergoing chemotherapy.

Method: A quantitative, analytical, prospective, longitudinal study was carried out in 44 patients diagnosed with breast cancer or lymphoma, who started chemotherapy treatment at the Instituto de Oncología y Radiobiología of Cuba, from February 2017 to April 2018. Primary and secondary methods were used for raw data collection and several statistical tests were used for its analysis.

Results: The mean age and treatment period were 47.7 years old and 5.05 months, respectively. The most prevalent risk factor was high blood pressure and cardiotoxicity was higher (27.8%) in patients with previous diastolic dysfunction. Among those who developed cardiotoxicity, the variable that showed the greatest affectation was global longitudinal strain (p<0.0001), with a reduction of 19.6% with respect to the basal one.

Conclusions: Global longitudinal strain is an echocardiographic index of myocardial performance, which presented a significant discriminating value with respect to cardiotoxicity in patients who received chemotherapeutic treatment.

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References

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Published

2021-01-16

How to Cite

1.
Torres González S, Hechavarria Pouymiró S, Fernández Cueto JA, Álvarez Plasencia R, González Corrales SC, Milán Roca D. Global longitudinal strain value in the early detection of chemotherapy-induced cardiotoxicity. CorSalud [Internet]. 2021 Jan. 16 [cited 2025 Jul. 1];13(1):32-43. Available from: https://revcorsalud.sld.cu/index.php/cors/article/view/687

Issue

Vol. 13 No. 1 (2021)

Section

ORIGINAL ARTICLES

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