J-wave in a patient with severe COVID-19
Abstract
In the context of the current COVID-19 epidemic, numerous are the manifestations of the infected patients, including the alterations in the 12-lead electrocardiogram, where the presence of a J-wave can be found, secondary to the generation of a transmural voltage gradient, caused by the overexpression of the channels for transient outward potassium current (Ito), in the context of a severe infection with extensive myocardial injury. In this article is presented the case of an 83-year-old patient with a positive diagnosis of COVID-19, who progressed to septic shock, with mixed acidosis and mild hyperkalemia. The electrocardiogram showed the presence of a J-wave, probably secondary to the effect of pro-inflammatory cytokines on potassium channels and extensive areas of myocardial injury.Downloads
References
1. Osborn JJ. Experimental hypothermia; respiratory and blood pH changes in relation to cardiac function. Am J Physiol. 1953;175(3):389-98. DOI: https://doi.org/10.1152/ajplegacy.1953.175.3.389
2. Antzelevitch C, Sicouri S, Litovsky SH, Lukas A, Krishnan SC, Di Diego JM, et al. Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells. Circ Res. 1991;69(6):1427-49. DOI: https://doi.org/10.1161/01.res.69.6.1427
3. Tomcsányi J, Arabadzisz H, Tomcsányi K. Osborn wave mimicking Brugada sign. Acta Cardiol. 2018;73(1):97. DOI: https://doi.org/10.1080/00015385.2017.1324671
4. Di Diego JM, Antzelevitch C. J wave syndromes as a cause of malignant cardiac arrhythmias. Pacing Clin Electrophysiol. 2018;41(7):684-99. DOI: https://doi.org/10.1111/pace.13408
5. Guo T, Fan Y, Chen M, Wu X, Zhang L, He T, et al. Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19). JAMA Cardiol. 2020;5(7):811-8. DOI: https://doi.org/10.1001/jamacardio.2020.1017
6. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. DOI: https://doi.org/10.1001/jama.2020.1585
7. De la Torre Fonseca LM. Lesión miocárdica en el paciente con COVID-19. CorSalud [Internet]. 2020 [citado 27 Mar 2021];12(2):171-83. Disponible en: https://revcorsalud.sld.cu/index.php/cors/article/view/623/1161
8. Macfarlane PW, Antzelevitch C, Haissaguerre M, Huikuri HV, Potse M, Rosso R, et al. The Early Repolarization Pattern: A Consensus Paper. J Am Coll Cardiol. 2015;66(4):470-7. DOI: https://doi.org/10.1016/j.jacc.2015.05.033
9. Lazzerini PE, Capecchi PL, Laghi-Pasini F. Systemic inflammation and arrhythmic risk: lessons from rheumatoid arthritis. Eur Heart J. 2017;38(22):1717-27. DOI: https://doi.org/10.1093/eurheartj/ehw208
10. Petkova-Kirova PS, Gursoy E, Mehdi H, McTiernan CF, London B, Salama G. Electrical remodeling of cardiac myocytes from mice with heart failure due to the overexpression of tumor necrosis factor-alpha. Am J Physiol Heart Circ Physiol. 2006;290(5):H2098-107. DOI: https://doi.org/10.1152/ajpheart.00097.2005
11. Li YH, Rozanski GJ. Effects of human recombinant interleukin-1 on electrical properties of guinea pig ventricular cells. Cardiovasc Res. 1993;27(3):525-30. DOI: https://doi.org/10.1093/cvr/27.3.525
12. Shimizu M, Nishizaki M, Yamawake N, Fujii H, Sakurada H, Isobe M, et al. J wave and fragmented QRS formation during the hyperacute phase in Takotsubo cardiomyopathy. Circ J. 2014;78(4):943-9. DOI: https://doi.org/10.1253/circj.cj-13-1296
13. Panginikkod S, Gupta NM, Gopalakrishnan V, Songolo T, Parikh MP, Friedman HJ. 'J' waves and hypothermia. QJM. 2018;111(12):903-4. DOI: https://doi.org/10.1093/qjmed/hcy138
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.