Relevance of the electrocardiogram in the diagnosis of left ventricular hypertrophy of patients on hemodialysis

Authors

  • Ana M. Suárez Conejero
  • Yuliet Lemus Almaguer
  • Dulce M. Meirelis Delgado
  • Mariana Otero Suárez

Abstract

Introduction: Left ventricular hypertrophy (LVH) is the most frequent structural cardiac alteration in patients with chronic kidney disease on hemodialysis. The electrocardiogram is the initial diagnostic resource used in the dialysis units for identification.

Objective: To evaluate the usefulness of the electrocardiogram in the diagnosis of LVH in patients with chronic kidney disease on hemodialysis.

Method: A total of 80 patients on hemodialysis were studied. The sensitivity, specificity and predictive values of seven electrocardiographic criteria of LVH were analyzed and correlated with the echocardiographic findings.

Results:  LVH was identified by the electrocardiogram in 33 hemodialysis patients (41% of cases). The electrocardiogram showed 50% of sensitivity, 82% of specificity and 87% of positive predictive value in the diagnosis of LVH. The Sokolow-Lyon voltage was the most useful criterion for the diagnosis of LVH, due to its higher sensitivity (43%), high specificity (86%) and positive predictive value (89%). The pattern of systolic overload of the left ventricular prevailed among the diagnostic criteria of the Romhilt-Estes score. The Sokolow-Lyon voltage was the most useful criterion for detecting concentric forms of hypertrophy, whereas the voltage criterion of the R wave in aVL was the most useful for detecting severe forms.

Conclusions: The electrocardiogram is a useful diagnostic tool to certify the existence of LVH in patients with chronic kidney disease on hemodialysis. Its diagnostic utility is greater when it comes to identify concentric and severe forms of LVH.

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References

1. Kanbay M, Afsar B, Goldsmith D, Covic A. Sudden death in hemodialysis: An Update. Blood Purif. 2010;30(2):135-45.

2. Bright R. Cases and observations, illustrative of renal disease accompanied with the secretion of albuminous urine. Guy’s Hosp Rep [Internet]. 1836 [citado 22 Ago 2017];1(2):338-379. Disponible en: https://babel.hathitrust.org/cgi/pt?id=iau.31858046169490;view=1up;seq=390

3. Middleton RJ, Parfrey PS, Foley RN. Left ventricular hypertrophy in the renal patient. J Am Soc Nephrol. 2001;12(5):1079-84.

4. Foley RN, Parfrey PS, Harnett JD, Kent GM, Murray DC, Barré PE. The prognostic importance of left ventricular geometry in uremic cardiomyopathy. J Am Soc Nephrol. 1995;5(12):2024-31.

5. Levin A, Thompson CR, Ethier J, Carlisle EJ, Tobe S, Mendelssohn D, et al. Left ventricular mass index increase in early renal disease: Impact of decline in hemoglobin. Am J Kidney Dis. 1999;34(1):125-34.

6. Truong QA, Ptaszek LM, Charipar EM, Taylor C, Fontes JD, Kriegel M, et al. Performance of electrocardiographic criteria for left ventricular hypertrophy as compared with cardiac computed tomography: from the Rule Out Myocardial Infarction Using Computer Assisted Tomography trial. J Hypertens. 2010;28(9):1959-67.

7. Levy D, Labib SB, Anderson KM, Christiansen JC, Kannel WB, Castelli WP. Determinants of sensitivity and specificity of electrocardiographic criteria for left ventricular hypertrophy. Circulation. 1990;81(3):815-20.

8. Calderón A, Barrios V, Escobar C, Ferrer E, Barrios S, González-Pedel V, et al. Detection of left ventricular hypertrophy by different electrocardiographic criteria in clinical practice. Findings from the Sara study. Clin Exp Hypertens. 2010;32(3):145-53.

9. Okin PM, Roman MJ, Devereux RB, Kligfield P. Electrocardiographic identification of increased left ventricular mass by simple voltage-duration products. J Am Coll Cardiol. 1995;25(2):417-23.

10. Smilde TD, Asselbergs FW, Hillege HL, Voors AA, Kors JA, Gansevoort RT, et al. Mild renal dysfunction is associated with electrocardiographic left ventricular hypertrophy. Am J Hypertens. 2005;18(3):342-7.

11. Verdecchia P, Schillaci G, Borgioni C, Ciucci A, Gattobigio R, Zampi I, et al. Prognostic value of a new electrocardiographic method for diagnosis of left ventricular hypertrophy in essential hypertension. J Am Coll Cardiol. 1998;31(2):383-90.

12. Kim SJ, Oh HJ, Yoo DE, Shin DH, Lee MJ, Kim HR, et al. Electrocardiographic left ventricular hypertrophy and outcome in hemodialysis patients. PLoS ONE [Internet]. 2012 [citado 22 Ago 2017];7(4):e35534. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328457/pdf/pone.0035534.pdf

13. Costa F de A, Rivera IR, Vasconcelos ML, Costa AF, Póvoa RM, Bombig MT, et al. Electrocardiography in the diagnosis of ventricular hypertrophy in patients with chronic renal disease. Arq Bras Cardiol. 2009;93(4):353-9.

14. Cordeiro AC, Moraes AA, Cerutti V, França F, Quiroga B, Amodeo C, et al. Clinical determinants and prognostic significance of the electrocardiographic strain pattern in chronic kidney disease patients. J Am Soc Hypertens. 2014;8(5):312-20.

15. Covic AC, Buimistriuc LD, Green D, Stefan A, Badarau S, Kalra PA. The prognostic value of electrocardiographic estimation of left ventricular hypertrophy in dialysis patients. Ann Noninvasive Electrocardiol. 2013;18(2):188-98.

16. Kligfield P, Gettes LS, Bailey JJ, Childers R, Deal BJ, Hancock EW,et al. Recommendations for the standardization and interpretation of the electrocardiogram. Part I: The electrocardiogram and its technology: A scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Circulation. 2007;115(10):1306-24.

17. Hancock EW, Deal BJ, Mirvis DM, Okin P, Kligfield P, Gettes LS, et al. AHA/ACCF/HRS Recommendations for the standardization and interpretation of the electrocardiogram. Part V: Electrocardiogram changes associated with cardiac chamber hypertrophy: A scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. J Am Coll Cardiol. 2009;53(11):992-1002.

18. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification. Eur J Echocardiogr. 2006;7(2):79-108.

19. Devereux RB, Reichek N. Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. Circulation. 1977;55(4):613-8.

20. Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, et al. Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings. Am J Cardiol. 1986;57(6):450-8.

21. Koren MJ, Devereux RB, Casale PN, Savage DD, Laragh JH. Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension. Ann Intern Med. 1991;114(5):345-52.

22. Okin PM, Devereux RB, Jern S, Julius S, Kjeldsen SE, Dahlöf B. Relation of echocardiographic left ventricular mass and hypertrophy to persistent electrocardiographic left ventricular hypertrophy in hypertensive patients: the LIFE Study. Am J Hypertens. 2001;14(8 Pt 1):775-82.

23. Ganau A, Devereux RB, Roman MJ, de Simone G, Pickering TG, Saba PS, et al. Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension. J Am Coll Cardiol. 1992;19(7):1550-8.

24. Candebat Fernández OA, Rodríguez Bell Z, Rodríguez Bell V, Torres Candebat F, Callejas Candebat S. Tratamiento hemodialítico y evolución de los ancianos con insuficiencia renal crónica. MEDISAN [Internet]. 2009 [citado 30 Ago 2017];13(5). Disponible en: http://scielo.sld.cu/pdf/san/v13n5/san02509.pdf

25. Astan R, Akpinar I, Karan A, Kacmaz F, Sokmen E, Baysal E, et al. The effect of hemodialysis on electrocardiographic parameters. Ann Noninvasive Electrocardiol. 2015;20(3):253-7.

26. Dalas M, Vázquez A, Fernández Y, Guerra G. Comportamiento de factores pronósticos de morbilidad y mortalidad en una Unidad de Hemodiálisis. Rev Cubana Med [Internet]. 2008 [citado 22 Ago 2017];47(3). Disponible en: http://scielo.sld.cu/pdf/med/v47n3/med01308.pdf

27. Burton JO, Korsheed S, Grundy BJ, McIntyre CW. Hemodialysis-induced left ventricular dysfunction is associated with an increase in ventricular arrhythmias. Ren Fail. 2008;30(7):701-9.

28. Anuario Cuba Nefro-Red 2014. Situación de la Enfermedad Renal Crónica en Cuba 2014. 3er Año [Internet]. 2015 [citado 30 Ago 2017]. Disponible en: http://files.sld.cu/nefrologia/files/2015/09/anuario-nefrologia-2014-pagina-web-especialidad.pdf

29. Bozbas H, Atar I, Yildirir A, Ozgul A, Uyar M, Ozdemir N, et al. Prevalence and predictors of arrhythmia in end stage renal disease patients on hemodialysis. Ren Fail. 2007;29(3):331-9.

30. Kaze FF, Kengne AP, Djalloh AM, Ashuntantang G, Halle MP, Menanga AP, et al. Pattern and correlates of cardiac lesions in a group of sub-Saharan African patients on maintenance hemodialysis. Pan Afr Med J [Internet]. 2014 [citado 22 Ago 2017];17:3. Disponible en: http://www.panafrican-med-journal.com/content/article/17/3/pdf/3.pdf

31. Quiroga B, Villaverde M, Abad S, Vega A, Reque J, López-Gómez J M. Diastolic dysfunction and high levels of new cardiac biomarkers as risk factors for cardiovascular events and mortality in hemodialysis patients. Blood Purif. 2013;36(2):98-106.

32. Genovesi S, Rossi E, Nava M, Riva H, de Franceschi S, Fabbrini P, et al. A case series of chronic haemodialysis patients: Mortality, sudden death, and QT interval. Europace. 2013;15(7):1025-33.

33. Valentim B, Pereira A, Coelho P, Pereira T. Study of ventricular electrical systole in patients with end-stage kidney disease on hemodialysis. Arq Bras Cardiol. 2013;100(3):261-8.

34. Mohi-ud-din K, Bali HK, Banerjee S, Sakhuja V, Jha V. Silent myocardial ischemia and high-grade ventricular arrhythmias in patients on maintenance hemodialysis. Ren Fail. 2005;27(2):171-5.

35. Stewart GA, Gansevoort RT, Mark PB, Rooney E, McDonagh TA, Dargie HJ, et al. Electrocardiographic abnormalities and uremic cardiomyopathy. Kidney Int. 2005;67(1):217-26.

36. Gorsane I, Mahfoudhi M, Younsi F, Helal I, Abdallah TB. Prevalence and risk factors of hypertension in hemodialysis. Open J Nephrol [Internet]. 2015 [citado 22 Ago 2017];5:54-60. Disponible en: http://file.scirp.org/pdf/OJNeph_2015061615315861.pdf

37. Ministerio de Salud Pública. Anuario Estadístico de Salud 2014. La Habana: Dirección Nacional de Registros Médicos y Estadísticas de Salud; 2015.

38. Krane V, Heinrich F, Meesmann M, Olschewski M, Lilienthal J, Angermann C, et al. Electrocardiography and outcome in patients with diabetes mellitus on maintenance hemodialysis. Clin J Am Soc Nephrol. 2009;4(2):394-400.

39. Paoletti E, Specchia C, Di Maio G, Bellino D, Damasio B, Cassottana P, et al. The worsening of left ventricular hypertrophy is the strongest predictor of sudden cardiac death in haemodialysis patients: A 10 year survey. Nephrol Dial Transplant. 2004;19(7):1829-34.

40. Glassock RJ, Pecoits-Filho R, Barberato SH. Left ventricular mass in chronic kidney disease and ESRD. Clin J Am Soc Nephrol. 2009;4(Supl 1):S79-91.

41. London GM, Pannier B, Guerin AP, Blacher J, Marchais SJ, Darne B, et al. Alterations of left ventricular hypertrophy in and survival of patients receiving hemodialysis: Follow-up of an interventional study. J Am Soc Nephrol. 2001;12(12):2759-67.

42. Taddei S, Nami R, Bruno RM, Quatrini I, Nuti R. Hypertension, left ventricular hypertrophy and chronic kidney disease. Heart Fail Rev. 2011;16(6):615-20.

43. Bignotto LH, Kallás ME, Djouki RJ, Sassaki MM, Voss GO, Soto CL, et al. Electrocardiographic findings in chronic hemodialysis patients. J Bras Nefrol. 2012;34(3):235-42.

44. Agarwal R, Light RP. Determinants and prognostic significance of electrocardiographic left ventricular hypertrophy criteria in chronic kidney disease. Clin J Am Soc Nephrol. 2011;6:528-36.

45. Bayés de Luna A. Electrocardiografía clínica. 7ª ed. Barcelona: Wiley-Blackwell; 2012. p. 127-63.

46. Kannel WB, Levy D, Cupples LA. Left ventricular hypertrophy and risk of cardiac failure: insights from the Framingham Study. J Cardiovasc Pharmacol. 1987;10(Supl 6):S135-40.

47. Buchner S, Debl K, Haimerl J, Djavidani B, Poschenrieder F, Feuerbach S, et al. Electrocardiographic diagnosis of left ventricular hypertrophy in aortic valve disease: evaluation of ECG criteria by cardiovascular magnetic resonance. J Cardiovasc Magn Reson [Internet]. 2009 [citado 30 Ago 2017];11:18. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696426/pdf/1532-429X-11-18.pdf

48. Alfakih K, Walters K, Jones T, Ridgway J, Hall AS, Sivananthan M. New gender-specific partition values for ECG criteria of left ventricular hypertrophy: recalibration against cardiac MRI. Hypertension. 2004;44(2):175-9.

Published

2018-01-13

How to Cite

1.
Suárez Conejero AM, Lemus Almaguer Y, Meirelis Delgado DM, Otero Suárez M. Relevance of the electrocardiogram in the diagnosis of left ventricular hypertrophy of patients on hemodialysis. CorSalud [Internet]. 2018 Jan. 13 [cited 2025 Jun. 22];10(1):21-3. Available from: https://revcorsalud.sld.cu/index.php/cors/article/view/290

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ORIGINAL ARTICLES